M024080

ssH-Linker

configured for PerkinElmer, configured for Polygen

• 别名: 9,11-Dioxa-2-aza-10-phosphatridecanoic acid, 10-[bis(1-methylethyl)amino]-13-cyano-, 2-[[(4-methoxyphenyl)diphenylmethyl]amino]ethyl este
• 经验公式（希尔记法）: C₃₈H₅₃N₄O₅P
• 分子量: 676.83
• MDL號碼: MFCD12912425
• 分類程式碼代碼: 12352200
• PubChem物質ID: 329817759
• NACRES: NA.51

属性

• 種類: for DNA synthesis
• 品質等級: 200
• 產品線: Proligo Reagents
• 化驗: ≥98% (³¹P-NMR); ≥98.0% (reversed phase HPLC)
• 相容性: configured for PerkinElmer; configured for Polygen
• 儲存溫度: −20°C
• SMILES 字串: COc1ccc(cc1)C(NCCOC(=O)NCCCCCCOP(OCCC#N)N(C(C)C)C(C)C)(c2ccccc2)c3ccccc3
• InChI: 1S/C38H53N4O5P/c1-31(2)42(32(3)4)48(47-29-16-25-39)46-28-15-7-6-14-26-40-37(43)45-30-27-41-38(33-17-10-8-11-18-33,34-19-12-9-13-20-34)35-21-23-36(44-5)24-22-35/h8-13,17-24,31-32,41H,6-7,14-16,26-30H2,1-5H3,(H,40,43)
• InChI 密鑰: VTFLXOVDKJUHER-UHFFFAOYSA-N

说明

一般說明

ssH-linker comprises an internal carbamate group attached to the MMT-protected amino group via a short spacer. The carbamate moiety facilitates the cleavage of the MMT group under mildly acidic conditions while increasing the stability of the MMT group during the deprotection of the oligonucleotide with ammonia. The carbamate group also enhances the reactivity of the amino group through a neighbor group effect, and thereby accelerates conjugations to amino reactive modifiers and reporters. The MMT-group of ssH-linker serves as an excellent purification handle after the oligonucleotide synthesis in trityl-on mode, similar to the DMT-group of conventional oligonucleotides. The MMT-group is cleaved under very mild conditions in aqueous acetic acid (10% glacial acetic acid in the water, 20 min. room temp.) Alternatively, the MMT-group can be cleaved on the synthesis instrument with an acidic deblock solution to enable on-support labeling protocols.

法律資訊

This product is covered under US Patent Number 7,491,857

安全信息

• 儲存類別代碼: 11 - Combustible Solids
• 水污染物質分類（WGK）: WGK 3
• 閃點（°F）: Not applicable
• 閃點（°C）: Not applicable