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Merck
所有图片(1)

主要文件

LO4200

Sigma-Aldrich

LOPAC®1280 - Small Scale

International Version

别名:

药理活性化合物库-小规模

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About This Item

EC號碼:
分類程式碼代碼:
12352200
NACRES:
NA.77

品質等級

形狀

liquid

運輸包裝

dry ice

儲存溫度

−20°C

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一般說明

化合物以 96 孔格式排列在 16 个 80 的管架中,每个孔一个化合物(25 μl,10 mM,DMSO 溶液,在存档存储架中)。

應用

药理活性化合物数据库(LOPAC)®1280 - 小规模已被用于筛查氯硝柳胺和尼日利亚菌素诱发的白细胞介素(IL-1β) 释放抑制剂。

特點和優勢

包括细胞信号& 神经科学领域中最新的类药物分子 :

  • 细胞凋亡
  • G 蛋白 & 环核苷酸
  • 基因调控 & 表达
  • 离子通道
  • 脂质信号
  • 多重耐药性
  • 神经传递
  • 磷酸化
提供 SDFile 来构建包含以下内容的数据库:
  • 结构
  • 主要名称
  • 次要名称
  • 药理活性
  • 货号
  • 管架位置

其他說明

仅限美国境外销售。美国客户应参考货号 LO4100

法律資訊

LOPAC is a registered trademark of Merck KGaA, Darmstadt, Germany

訊號詞

Danger

危險分類

Acute Tox. 2 Dermal - Acute Tox. 2 Inhalation - Acute Tox. 2 Oral - Aquatic Acute 1 - Aquatic Chronic 1 - Carc. 1A - Eye Dam. 1 - Lact. - Muta. 1B - Repr. 1A - Resp. Sens. 1 - Skin Corr. 1B - Skin Sens. 1 - STOT RE 2 - STOT SE 2

儲存類別代碼

6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials

閃點(°F)

188.6 °F

閃點(°C)

87 °C


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High-throughput screening identifies compounds that enhance lentiviral transduction.
Johnston JM, Denning G, Moot R, et al.
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High genetic and phenotypic variability between Leishmania species and strains within species make the development of broad-spectrum antileishmanial drugs challenging. Thus, screening panels consisting of several diverse Leishmania species can be useful in enabling compound prioritization based on their spectrum
Kurumi Y Horiuchi et al.
Assay and drug development technologies, 11(4), 227-236 (2013-04-06)
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The galanin 3 receptor (GalR3) belongs to the large G protein-coupled receptor (GPCR) family of proteins. GalR3 and two other closely related receptors, GalR1 and GalR2, together with their endogenous ligand galanin, are involved in a variety of physiological and
John S Lazo et al.
Molecular pharmacology, 72(1), 1-7 (2007-04-05)
Small molecules are powerful pharmacological tools to dissect biological events. There is now considerable interest in expanding efforts to identify and use small molecules targeting proteins encoded in the genomes of humans and pathogenic organisms. Integration of the principles of

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