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L5768

Sigma-Aldrich

羊毛甾醇

≥93%, powder

别名:

3β-羟基-8，24-羊毛二烯, 8，24-羊毛甾烷-3β-醇

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About This Item

经验公式（希尔记法）:
C30H50O
CAS号:
79-63-0
分子量:
426.72
EC號碼:
201-214-9
MDL號碼:
MFCD00021108
分類程式碼代碼:
12352211
PubChem物質ID:
24896417
NACRES:
NA.77

品質等級

200

化驗

≥93%

形狀

powder

顏色

white to off-white

儲存溫度

−20°C

SMILES 字串

[H][C@@]1(CC[C@@]2(C)C3=C(CC[C@]12C)[C@@]4(C)CC[C@H](O)C(C)(C)[C@]4([H])CC3)[C@H](C)CC\C=C(/C)C

InChI

1S/C30H50O/c1-20(2)10-9-11-21(3)22-14-18-30(8)24-12-13-25-27(4,5)26(31)16-17-28(25,6)23(24)15-19-29(22,30)7/h10,21-22,25-26,31H,9,11-19H2,1-8H3/t21-,22-,25+,26+,28-,29-,30+/m1/s1

InChI 密鑰

CAHGCLMLTWQZNJ-BQNIITSRSA-N

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一般說明

羊毛甾醇作为一种两亲水脂分子，由羊毛甾醇合酶(LSS)产生，可在晶状体中富集。

應用

羊毛甾醇用于：
  • 作为在HPLC在睾丸样本量化中的标准
  • 用于S-腺苷-L-蛋氨酸：Δ24-甾醇-C-甲基转移酶(SMT)分析
  • 处理在丰富培养基中生长的野生型细胞，了解其对Sre1蛋白的影响

生化／生理作用

胆固醇前体甾醇。
羊毛甾醇用作巨噬细胞免疫的内源性选择性调节剂。

儲存類別代碼

11 - Combustible Solids

水污染物質分類（WGK）

WGK 1

閃點（°F）

Not applicable

閃點（°C）

Not applicable

個人防護裝備

Eyeshields, Gloves, type N95 (US)

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Xiao-Jing Guo et al.
Biotechnology for biofuels, 11, 192-192 (2018-07-22)
7-Dehydrocholesterol (7-DHC) has attracted increasing attentions due to its great medical value and the enlarging market demand of its ultraviolet-catalyzed product vitamin D3. Microbial production of 7-DHC from simple carbon has been recognized as an attractive complement to the traditional
Lorena Fernández-Cabezón et al.
Frontiers in microbiology, 9, 958-958 (2018-06-06)
Nowadays steroid manufacturing occupies a prominent place in the pharmaceutical industry with an annual global market over $10 billion. The synthesis of steroidal active pharmaceutical ingredients (APIs) such as sex hormones (estrogens, androgens, and progestogens) and corticosteroids is currently performed
Identification and Characterization of an S-Adenosyl-L-methionine:-Sterol-C-methyltransferase cDNA from Soybean
Shi J, et al.
The Journal of Biological Chemistry, 271(16), 9384-9389 (1996)
Lanosterol reverses protein aggregation in cataracts
Zhao L, et al.
Nature, 523(7562), 607-607 (2015)
Evgeniy O Yablokov et al.
Biochimie, 162, 156-166 (2019-04-30)
The aim of the present work was to establish the thermodynamic and functional differences in the protein-protein interactions between the components of the P450-dependent mitochondrial (mit) and microsomal (mic) monooxygenase systems using 12 different isoforms of cytochromes P450 and two
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Cholesterol Biosynthesis

Biosynthesis of cholesterol generally takes place in the endoplasmic reticulum of hepatic cells and begins with acetyl- CoA, which is mainly derived from an oxidation reaction in the mitochondria. Acetyl-CoA and acetoacetyl-CoA are converted to 3-hydroxy- 3-methylglutaryl-CoA (HMG-CoA) by HMG-CoA synthase.

Cholesterol Biosynthesis

Biosynthesis of cholesterol generally takes place in the endoplasmic reticulum of hepatic cells and begins with acetyl- CoA, which is mainly derived from an oxidation reaction in the mitochondria. Acetyl-CoA and acetoacetyl-CoA are converted to 3-hydroxy- 3-methylglutaryl-CoA (HMG-CoA) by HMG-CoA synthase.

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