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重組細胞
expressed in E. coli
品質等級
描述
200 amino acid residue methionyl form of mature, recombinant human prolactin (amino acid residues 29-227).
產品線
BioReagent
化驗
>97% (SDS-PAGE)
形狀
lyophilized powder
效力
0.030-0.300 ng/mL EC50
分子量
predicted mol wt ~24 kDa
技術
cell culture | mammalian: suitable
雜質
endotoxin, tested
溶解度
water: 0.5000 mL, clear, colorless
UniProt登錄號
運輸包裝
ambient
儲存溫度
−20°C
基因資訊
human ... PRL(5617)
應用
可用在细胞培养应用中研究催乳素对细胞信号传导和基因表达的调节。
生化／生理作用
催乳素是一种神经内分泌激素。催乳激素受体是一种跨膜糖蛋白，属于细胞因子造血受体家族。大量细胞和器官表达该受体，包括 B 细胞、T 细胞、巨噬细胞、单核细胞和嗜中性粒细胞。催乳素信号转导涉及 JAK/STAT 家族和 src 激酶家族。引起泌乳；抑制促性腺激素的分泌；释放受多巴胺抑制。
其他說明
包含天然产物中不存在的 N 末端甲硫氨酸。
外觀
从 10mM 磷酸盐和 50mM 氯化钠溶液（pH 8.0）中冻干。
重構
建议将无菌 4 mM HCl（含 1 mg/mL 牛血清白蛋白）添加到小瓶中，以制备不低于 100 μg/mL 的储液。
分析報告
生物学活性是通过大鼠淋巴瘤细胞系 Nb2-11 的增殖实验测定的。
訊號詞
Danger
危險聲明
危險分類
Repr. 1B
儲存類別代碼
6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
水污染物質分類（WGK）
WGK 3
閃點（°F）
Not applicable
閃點（°C）
Not applicable
其他客户在看
Regulatory action of prolactin on the in vitro growth of CD34+ve human hemopoietic progenitor cells.
G Bellone et al.
Journal of cellular physiology, 163(2), 221-231 (1995-05-01)
The pituitary hormone prolactin (Prl) is known to act as a local regulator of immune cell function, and Prl-binding receptors (Prl-R) have been described to share distinctive features with the members of the newly described cytokine/hemopoietin receptor superfamily. Here we
Extrapituitary prolactin: distribution, regulation, functions, and clinical aspects.
N Ben-Jonathan et al.
Endocrine reviews, 17(6), 639-669 (1996-12-01)
Khalid Bajou et al.
Nature medicine, 20(7), 741-747 (2014-06-16)
The N-terminal fragment of prolactin (16K PRL) inhibits tumor growth by impairing angiogenesis, but the underlying mechanisms are unknown. Here, we found that 16K PRL binds the fibrinolytic inhibitor plasminogen activator inhibitor-1 (PAI-1), which is known to contextually promote tumor
Etienne Delgrange et al.
European journal of endocrinology, 170(1), 31-38 (2013-10-04)
To characterise distinctive clinical features of giant prolactinomas in women. A multicentre, retrospective case series and literature review. We collected data from 15 female patients with a pituitary tumour larger than 4 cm and prolactin levels above 1000 μg/l and
Akie Nakamura et al.
The Journal of clinical endocrinology and metabolism, 98(10), E1682-E1691 (2013-08-24)
Congenital central hypothyroidism (C-CH) is a rare disease. We investigated the molecular basis of unexplained C-CH in 4 Japanese boys. C-CH was diagnosed by low free T4 and/or T3 and low basal TSH concentrations. We used whole-exome sequencing of one
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