推荐产品
生物源
rabbit
共軛
unconjugated
抗體表格
IgG fraction of antiserum
抗體產品種類
primary antibodies
無性繁殖
polyclonal
形狀
buffered aqueous solution
物種活性
rat, mouse, human
包裝
antibody small pack of 25 μL
技術
immunohistochemistry: suitable using suitable for IHC on rat brain perfused with 4% paraformaldehyde
microarray: suitable
western blot: 1:2,000 using rat brain homogenate and whole cell extract of rat pheochromocytoma PC12 cell line.
UniProt登錄號
運輸包裝
dry ice
儲存溫度
−20°C
目標翻譯後修改
unmodified
基因資訊
human ... KIF3A(11127)
mouse ... Kif3a(16568)
rat ... Kif3a(84392)
一般說明
KIF3A/B is abundantly expressed in neuronal tissue and ubiquitously expressed in other tissues in lower amounts.
The gene KIF3A (kinesin family member 3A) is mapped to human chromosome 5q31.1. The gene encodes a subunit of heterotrimeric kinesin-2, which is a canonical plus-oriented anterograde IFT (intraflagellar transport) motor.
免疫原
synthetic peptide corresponding to the C-terminus of mouse KIF3A (amino acids 682-701) conjugated to KLH.
應用
Anti-KIF3A antibody produced in rabbit has been used in immunohistochemistry and immunofluorescence.
Anti-KIF3A antibody produced in rabbit has been used in:
- immunoblotting
- immunohistochemical detection of kinesin family member 3A (KIF3A)
生化／生理作用
The gene KIF3A (kinesin family member 3A) encodes a motor subunit of kinesin-2, a protein that functions in the formation and mechanism of cilia. The chromosomal region to which the gene is mapped is linked to immune diseases, such as asthma.
The kinesin superfamily (KIFs) of proteins consists of a class of microtubule-dependent motors that plays a major role in many cellular and developmental functions, including organelle transport, mitosis, meiosis, and possibly long-range signaling in neurons. KIF3 plays a crucial role during development. KIF3A-/- and KIF3B-/- mice do not survive beyond mid-gestation. Embryos lacking KIF3A and KIF3B display randomization of left-right asymmetry and numerous morphological abnormalities. The KIF3A/B heterodimer exhibits a plus end-directed microtubule sliding activity.
外觀
0.01M 磷酸缓冲盐溶液，pH 7.4，含 15mM 叠氮化钠。
免責聲明
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
未找到合适的产品？
试试我们的产品选型工具.
儲存類別代碼
10 - Combustible liquids
水污染物質分類（WGK）
WGK 2
閃點（°F）
Not applicable
閃點（°C）
Not applicable
Kinesin family 17 (osmotic avoidance abnormal-3) is dispensable for photoreceptor morphology and function
Jiang L, et al.
Faseb Journal (2015)
Left-Right Asymmetry and Kinesin Superfamily Protein KIF3A: New Insights in Determination of Laterality and Mesoderm Induction by kif3A
Takeda S, et al.
The Journal of cell biology, 145(4), 825-825 (1999)
Investigating primary cilia in cultured metanephric mesenchymal cells.
Chi L and Rosenblum N
Methods in Molecular Biology, 886, 157-163 (2012)
Gene Expression Differences Predict Treatment Outcome of Merkel Cell Carcinoma Patients
Masterson L, et al.
Journal of Skin Cancer, 2014 (2014)
KIF3A/B: a heterodimeric kinesin superfamily protein that works as a microtubule plus end-directed motor for membrane organelle transport.
Yamazaki H, et al.
The Journal of Cell Biology, 130(6), 1387-1399 (1995)
我们的科学家团队拥有各种研究领域经验，包括生命科学、材料科学、化学合成、色谱、分析及许多其他领域.
联系技术服务部门