推荐产品
生物源
rabbit
共軛
unconjugated
抗體表格
affinity isolated antibody
抗體產品種類
primary antibodies
無性繁殖
polyclonal
產品線
Prestige Antibodies® Powered by Atlas Antibodies
形狀
buffered aqueous glycerol solution
物種活性
human
加強驗證
orthogonal RNAseq
independent
Learn more about Antibody Enhanced Validation
技術
immunoblotting: 0.04-0.4 μg/mL
immunohistochemistry: 1:2500-1:5000
免疫原序列
LQAAFSQYKKVELFPNGQSVGEKIFKTAGFVKPFTEAQLLCTQAGGQLASPRSAAENAALQQLVVAKNEAAFLSMTD
UniProt登錄號
運輸包裝
wet ice
儲存溫度
−20°C
目標翻譯後修改
unmodified
基因資訊
human ... SFTPD(6441)
相关类别
一般說明
Surfactant protein D (SFTPD) is expressed majorly by alveolar type II cells of the lung, epithelial surfaces, amniotic fluid and serum. The gene is located on human chromosome 10q22.3. It consists of an N-terminal domain with two conserved cysteines, a collagen-like region, an α helical neck region and a C-type lectin carbohydrate recognition domain (CRD).
免疫原
surfactant protein D
應用
All Prestige Antibodies Powered by Atlas Antibodies are developed and validated by the Human Protein Atlas (HPA) project and as a result, are supported by the most extensive characterization in the industry.
The Human Protein Atlas project can be subdivided into three efforts: Human Tissue Atlas, Cancer Atlas, and Human Cell Atlas. The antibodies that have been generated in support of the Tissue and Cancer Atlas projects have been tested by immunohistochemistry against hundreds of normal and disease tissues and through the recent efforts of the Human Cell Atlas project, many have been characterized by immunofluorescence to map the human proteome not only at the tissue level but now at the subcellular level. These images and the collection of this vast data set can be viewed on the Human Protein Atlas (HPA) site by clicking on the Image Gallery link. We also provide Prestige Antibodies® protocols and other useful information.
The Human Protein Atlas project can be subdivided into three efforts: Human Tissue Atlas, Cancer Atlas, and Human Cell Atlas. The antibodies that have been generated in support of the Tissue and Cancer Atlas projects have been tested by immunohistochemistry against hundreds of normal and disease tissues and through the recent efforts of the Human Cell Atlas project, many have been characterized by immunofluorescence to map the human proteome not only at the tissue level but now at the subcellular level. These images and the collection of this vast data set can be viewed on the Human Protein Atlas (HPA) site by clicking on the Image Gallery link. We also provide Prestige Antibodies® protocols and other useful information.
Anti-SFTPD antibody produced in rabbit has been used in immunohistochemistry.
生化／生理作用
Surfactant protein D (SFTPD) plays an important role in innate immune system. It is linked to macrophage mediated inhibition of interleukin IL-12p40 via signal regulatory protein α (SIRPα)/ Rho-associated protein kinase (ROCK)/ extracellular signal regulated kinases (ERK) signalling pathway. The protein plays an anti-inflammatory role in lungs. SFTPD maintains surfactant homeostasis by regulating the structure of surfactant phospholipids.
特點和優勢
Prestige Antibodies® are highly characterized and extensively validated antibodies with the added benefit of all available characterization data for each target being accessible via the Human Protein Atlas portal linked just below the product name at the top of this page. The uniqueness and low cross-reactivity of the Prestige Antibodies® to other proteins are due to a thorough selection of antigen regions, affinity purification, and stringent selection. Prestige antigen controls are available for every corresponding Prestige Antibody and can be found in the linkage section.
Every Prestige Antibody is tested in the following ways:
Every Prestige Antibody is tested in the following ways:
- IHC tissue array of 44 normal human tissues and 20 of the most common cancer type tissues.
- Protein array of 364 human recombinant protein fragments.
聯結
Corresponding Antigen APREST80249
外觀
Solution in phosphate buffered saline, pH 7.2, containing 40% glycerol and 0.02% sodium azide.
法律資訊
Prestige Antibodies is a registered trademark of Merck KGaA, Darmstadt, Germany
免責聲明
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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儲存類別代碼
10 - Combustible liquids
水污染物質分類（WGK）
WGK 1
閃點（°F）
Not applicable
閃點（°C）
Not applicable
In defense of the lung: surfactant protein A and surfactant protein D
Kingma PS, et al.
Current Opinions in Pharmacology, 6(3), 277-283 (2006)
Structure binding relationship of human surfactant protein D and various lipopolysaccharide inner core structures
Reinhardt A, et al.
Journal of Structural Biology, 195(3), 387-395 (2016)
A common polymorphism in the SFTPD gene influences assembly, function, and concentration of surfactant protein D
Leth-Larsen R, et al.
Journal of Immunology, 174(3), 1532-1538 (2005)
Surfactant protein A genetic variants associate with severe respiratory insufficiency in pandemic influenza A virus infection
Herrera-Ramos E, et al.
Critical Care, 18(3), R127-R127 (2014)
Surfactant Protein D Inhibits Interleukin-12p40 Production by Macrophages Through the SIRPα/ROCK/ERK Signaling Pathway
Yamaguchi R, et al.
The American Journal of the Medical Sciences, 353(6), 559-567 (2017)
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