HPA043829
Anti-GFRA1 antibody produced in rabbit
Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution
别名:
Anti-GDNF family receptor alpha 1, Anti-GDNFR, Anti-GDNFRA, Anti-GFR-ALPHA-1, Anti-RET1L, Anti-RETL1, Anti-TRNR1
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所有图片(6)
About This Item
分類程式碼代碼:
12352203
人類蛋白質圖譜編號:
推荐产品
生物源
rabbit
品質等級
共軛
unconjugated
抗體表格
affinity isolated antibody
抗體產品種類
primary antibodies
無性繁殖
polyclonal
產品線
Prestige Antibodies® Powered by Atlas Antibodies
形狀
buffered aqueous glycerol solution
物種活性
human
技術
immunofluorescence: 0.25-2 μg/mL
immunohistochemistry: 1:200-1:500
免疫原序列
IGTVMTPNYIDSSSLSVAPWCDCSNSGNDLEECLKFLNFFKDNTCLK
UniProt登錄號
運輸包裝
wet ice
儲存溫度
−20°C
目標翻譯後修改
unmodified
基因資訊
human ... GFRA1(2674)
一般說明
Glial cell line-derived neurotropic factor receptor Α 1 (GFRA1) is a member of GDNF receptor Α family (GFRΑ). It is encoded by the gene mapped to human chromosome 10q25.
免疫原
GDNF family receptor alpha 1 recombinant protein epitope signature tag (PrEST)
應用
All Prestige Antibodies Powered by Atlas Antibodies are developed and validated by the Human Protein Atlas (HPA) project and as a result, are supported by the most extensive characterization in the industry.
The Human Protein Atlas project can be subdivided into three efforts: Human Tissue Atlas, Cancer Atlas, and Human Cell Atlas. The antibodies that have been generated in support of the Tissue and Cancer Atlas projects have been tested by immunohistochemistry against hundreds of normal and disease tissues and through the recent efforts of the Human Cell Atlas project, many have been characterized by immunofluorescence to map the human proteome not only at the tissue level but now at the subcellular level. These images and the collection of this vast data set can be viewed on the Human Protein Atlas (HPA) site by clicking on the Image Gallery link. We also provide Prestige Antibodies® protocols and other useful information.
The Human Protein Atlas project can be subdivided into three efforts: Human Tissue Atlas, Cancer Atlas, and Human Cell Atlas. The antibodies that have been generated in support of the Tissue and Cancer Atlas projects have been tested by immunohistochemistry against hundreds of normal and disease tissues and through the recent efforts of the Human Cell Atlas project, many have been characterized by immunofluorescence to map the human proteome not only at the tissue level but now at the subcellular level. These images and the collection of this vast data set can be viewed on the Human Protein Atlas (HPA) site by clicking on the Image Gallery link. We also provide Prestige Antibodies® protocols and other useful information.
生化／生理作用
Glial cell line-derived neurotropic factor receptor Α1 (GFRA1) acts as a co-receptor of tyrosine-protein kinase receptor (RET) for the growth factor GDNF (glial cell line-derived neurotropic factor). The encoded protein functions as a ligand-induced cell adhesion molecule (LICAM) to build specific synaptic contacts and stimulates presynaptic differentiation.The expression of this protein, along with GFRΑ3 and artemin (ARTN), might be useful in determining the prognosis of certain subsets of mammary carcinoma. Reduced expression of GFRA1 in neurons is associated with the pathogenesis of Alzheimer′s disease (AD). Therefore, administration of GFRΑ1 with GDNF and artemin into AD neurons can be a potential therapeutic method to improve cell survival.
特點和優勢
Prestige Antibodies® are highly characterized and extensively validated antibodies with the added benefit of all available characterization data for each target being accessible via the Human Protein Atlas portal linked just below the product name at the top of this page. The uniqueness and low cross-reactivity of the Prestige Antibodies® to other proteins are due to a thorough selection of antigen regions, affinity purification, and stringent selection. Prestige antigen controls are available for every corresponding Prestige Antibody and can be found in the linkage section.
Every Prestige Antibody is tested in the following ways:
Every Prestige Antibody is tested in the following ways:
- IHC tissue array of 44 normal human tissues and 20 of the most common cancer type tissues.
- Protein array of 364 human recombinant protein fragments.
聯結
Corresponding Antigen APREST84404
外觀
Solution in phosphate buffered saline, pH 7.2, containing 40% glycerol and 0.02% sodium azide.
法律資訊
Prestige Antibodies is a registered trademark of Merck KGaA, Darmstadt, Germany
免責聲明
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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儲存類別代碼
10 - Combustible liquids
水污染物質分類（WGK）
WGK 1
閃點（°F）
Not applicable
閃點（°C）
Not applicable
Deficiency of GDNF Receptor GFR?1 in Alzheimer's Neurons Results in Neuronal Death.
Konishi Y
The Journal of Neuroscience, 34, 13127-13138 (2014)
Human GFRA1: cloning, mapping, genomic structure, and evaluation as a candidate gene for Hirschsprung disease susceptibility.
Angrist M
Genomics, 48, 354-362 (1998)
Prognostic significance of the expression of GFR?1, GFR?3 and syndecan-3, proteins binding ARTEMIN, in mammary carcinoma.
Wu ZS
BMC Cancer (2013)
GDNF and GFRalpha1 promote formation of neuronal synapses by ligand-induced cell adhesion.
Ledda F
Nature Neuroscience, 10, 293-300 (2007)
Gfra1 silencing in mouse spermatogonial stem cells results in their differentiation via the inactivation of RET tyrosine kinase.
He Z
Biology of Reproduction, 77, 723-733 (2007)
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