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Merck
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Key Documents

HPA036227

Sigma-Aldrich

Anti-SLC7A7 antibody produced in rabbit

enhanced validation

Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution

别名:

Anti-LPI, Anti-Solute carrier family 7 (cationic amino acid transporter, y+ system), member 7, Anti-Y+LAT-1

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About This Item

分類程式碼代碼:
12352203
人類蛋白質圖譜編號:
NACRES:
NA.43

生物源

rabbit

品質等級

共軛

unconjugated

抗體表格

affinity isolated antibody

抗體產品種類

primary antibodies

無性繁殖

polyclonal

產品線

Prestige Antibodies® Powered by Atlas Antibodies

形狀

buffered aqueous glycerol solution

物種活性

human

加強驗證

recombinant expression
orthogonal RNAseq
Learn more about Antibody Enhanced Validation

技術

immunohistochemistry: 1:50-1:200
western blot: 0.04-0.4 μg/mL

免疫原序列

DSTEYEVASQPEVETSPLGDGASPGPEQVKLKK

UniProt登錄號

運輸包裝

wet ice

儲存溫度

−20°C

目標翻譯後修改

unmodified

基因資訊

human ... SLC7A7(9056)

一般說明

The gene SLC7A7 (solute carrier family 7 member 7) is mapped to human chromosome 14q11.2. It is an amino acid transporter and belongs to the SLC family of proteins. The gene encodes for y+LAT1 protein (the catalytic light chain subunit) which heterodimerizes with 4F2hc (the heavy chain subunit). Together, they result in y+L amino acid transport activity in the basolateral cell membrane of the epithelial cells of the renal proximal tubule and the small intestine.

免疫原

solute carrier family 7 (cationic amino acid transporter, y+ system), member 7 recombinant protein epitope signature tag (PrEST)

應用

All Prestige Antibodies Powered by Atlas Antibodies are developed and validated by the Human Protein Atlas (HPA) project and as a result, are supported by the most extensive characterization in the industry.

The Human Protein Atlas project can be subdivided into three efforts: Human Tissue Atlas, Cancer Atlas, and Human Cell Atlas. The antibodies that have been generated in support of the Tissue and Cancer Atlas projects have been tested by immunohistochemistry against hundreds of normal and disease tissues and through the recent efforts of the Human Cell Atlas project, many have been characterized by immunofluorescence to map the human proteome not only at the tissue level but now at the subcellular level. These images and the collection of this vast data set can be viewed on the Human Protein Atlas (HPA) site by clicking on the Image Gallery link. We also provide Prestige Antibodies® protocols and other useful information.

生化/生理作用

SLC7A7 (solute carrier family 7 member 7) is involved in influx/efflux of cationic and large neutral amino acids across membrane. The transporter works in a sodium-independent manner. SLC7A7 is associated with various cancers such as ovarian cancer, non-small cell lung cancer and multiple myeloma. It is upregulated in glioblastoma. Mutation in this gene is associated with lysinuric protein intolerance.

特點和優勢

Prestige Antibodies® are highly characterized and extensively validated antibodies with the added benefit of all available characterization data for each target being accessible via the Human Protein Atlas portal linked just below the product name at the top of this page. The uniqueness and low cross-reactivity of the Prestige Antibodies® to other proteins are due to a thorough selection of antigen regions, affinity purification, and stringent selection. Prestige antigen controls are available for every corresponding Prestige Antibody and can be found in the linkage section.

Every Prestige Antibody is tested in the following ways:
  • IHC tissue array of 44 normal human tissues and 20 of the most common cancer type tissues.
  • Protein array of 364 human recombinant protein fragments.

聯結

Corresponding Antigen APREST78549

外觀

Solution in phosphate buffered saline, pH 7.2, containing 40% glycerol and 0.02% sodium azide.

法律資訊

Prestige Antibodies is a registered trademark of Merck KGaA, Darmstadt, Germany

免責聲明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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儲存類別代碼

10 - Combustible liquids

水污染物質分類(WGK)

WGK 1

閃點(°F)

Not applicable

閃點(°C)

Not applicable


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访问文档库

Genetic variants in SLC7A7 are associated with risk of glioma in a Chinese population.
Fan S, et al.
Experimental Biology and Medicine (Maywood, N.J.), 238, 1075-1081 (2013)
Impaired phagocytosis in macrophages from patients affected by lysinuric protein intolerance.
Barilli A, et al.
Molecular Genetics and Metabolism, 105, 585-589 (2012)
Novel SLC7A7 large rearrangements in lysinuric protein intolerance patients involving the same AluY repeat.
Font-Llitjos M, et al.
European Journal of Human Genetics, 17, 71-79 (2009)
E Tina et al.
The British journal of dermatology, 180(1), 130-140 (2018-06-26)
The incidence of basal cell carcinoma (BCC) is increasing and the costs for care rising. Therefore, the need for simplified and cost-effective treatment choices is substantial. Aberrant signalling in several pathways, induced by ultraviolet radiation, is of importance in the
Lysinuric protein intolerance: update and extended mutation analysis of the SLC7A7 gene.
Sperandeo MP, et al.
Human Mutation, 29, 14-21 (2008)

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