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生物源
rabbit
品質等級
共軛
unconjugated
抗體表格
affinity isolated antibody
抗體產品種類
primary antibodies
無性繁殖
polyclonal
產品線
Prestige Antibodies® Powered by Atlas Antibodies
形狀
buffered aqueous glycerol solution
物種活性
human
加強驗證
RNAi knockdown
Learn more about Antibody Enhanced Validation
技術
immunoblotting: 0.04-0.4 μg/mL
immunofluorescence: 0.25-2 μg/mL
免疫原序列
PVPVSEPVPEPEPEPEPEPVKEEKLSPEPILVDTASPSPMETSGCAPAEEDLCQAFSDVILAVNDVDAEDGAD
UniProt登錄號
運輸包裝
wet ice
儲存溫度
−20°C
目標翻譯後修改
unmodified
基因資訊
human ... CCNB1(891)
一般說明
G2/mitotic-specific cyclin-B1 (CCNB1), also known as cyclin B1, regulates cell division in eukaryotes. It has N-terminal and C-terminal cyclin box motifs. CCNB1 is located on human chromosome 5q13.
免疫原
cyclin B1
應用
All Prestige Antibodies Powered by Atlas Antibodies are developed and validated by the Human Protein Atlas (HPA) project and as a result, are supported by the most extensive characterization in the industry.
The Human Protein Atlas project can be subdivided into three efforts: Human Tissue Atlas, Cancer Atlas, and Human Cell Atlas. The antibodies that have been generated in support of the Tissue and Cancer Atlas projects have been tested by immunohistochemistry against hundreds of normal and disease tissues and through the recent efforts of the Human Cell Atlas project, many have been characterized by immunofluorescence to map the human proteome not only at the tissue level but now at the subcellular level. These images and the collection of this vast data set can be viewed on the Human Protein Atlas (HPA) site by clicking on the Image Gallery link. We also provide Prestige Antibodies® protocols and other useful information.
The Human Protein Atlas project can be subdivided into three efforts: Human Tissue Atlas, Cancer Atlas, and Human Cell Atlas. The antibodies that have been generated in support of the Tissue and Cancer Atlas projects have been tested by immunohistochemistry against hundreds of normal and disease tissues and through the recent efforts of the Human Cell Atlas project, many have been characterized by immunofluorescence to map the human proteome not only at the tissue level but now at the subcellular level. These images and the collection of this vast data set can be viewed on the Human Protein Atlas (HPA) site by clicking on the Image Gallery link. We also provide Prestige Antibodies® protocols and other useful information.
生化／生理作用
Cyclin B1 (CCNB1) interacts with cyclin B1−associated kinase (Cdk1) and coordinates mitotic cycle events. CCNB1 is crucial for maintenance of cell division and arrest in the presence of antineoplastic agents. It is highly expressed in breast and small cell lung cancer. CCNB1 may play a key role in pathogenesis of pituitary adenomas.
特點和優勢
Prestige Antibodies® are highly characterized and extensively validated antibodies with the added benefit of all available characterization data for each target being accessible via the Human Protein Atlas portal linked just below the product name at the top of this page. The uniqueness and low cross-reactivity of the Prestige Antibodies® to other proteins are due to a thorough selection of antigen regions, affinity purification, and stringent selection. Prestige antigen controls are available for every corresponding Prestige Antibody and can be found in the linkage section.
Every Prestige Antibody is tested in the following ways:
Every Prestige Antibody is tested in the following ways:
- IHC tissue array of 44 normal human tissues and 20 of the most common cancer type tissues.
- Protein array of 364 human recombinant protein fragments.
聯結
Corresponding Antigen APREST89285
外觀
Solution in phosphate buffered saline, pH 7.2, containing 40% glycerol and 0.02% sodium azide.
法律資訊
Prestige Antibodies is a registered trademark of Merck KGaA, Darmstadt, Germany
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儲存類別代碼
10 - Combustible liquids
水污染物質分類（WGK）
WGK 1
閃點（°F）
Not applicable
閃點（°C）
Not applicable
Human cyclin B1 gene (CCNB1) assigned to chromosome 5 (q13-qter)
Milatovich A and Francke U
Somatic Cell and Molecular Genetics, 18(3), 303-307 (1992)
Upregulation of cyclin B1 plays potential roles in the invasiveness of pituitary adenomas
Zhao P, et al.
Journal of Clinical Neuroscience : Official Journal of the Neurosurgical Society of Australasia, 43(15), 267-273 (2017)
Overexpression of cyclin B1 in early-stage non-small cell lung cancer and its clinical implication
Soria JC, et al.
Cancer Research, 60(15), 4000-4004 (2000)
The crystal structure of human cyclin B
Petri ET, et al.
Cell Cycle, 6(11), 1342-1349 (2007)
Nuclear cyclin B1 in human breast carcinoma as a potent prognostic factor
Suzuki T, et al.
Cancer Science, 98(5), 644-651 (2007)
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