HPA001209

ANTI-SUN2 antibody produced in rabbit

Prestige Antibodies^® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution

• 别名: Anti-Rab5-interacting protein, Anti-Rab5IP, Anti-Sad1/unc-84-like protein 2, Anti-UNC84B
• 分類程式碼代碼: 12352203
• 人類蛋白質圖譜編號: HPA001209

属性

• 生物源: rabbit
• 品質等級: 100
• 共軛: unconjugated
• 抗體表格: affinity isolated antibody
• 抗體產品種類: primary antibodies
• 無性繁殖: polyclonal
• 產品線: Prestige Antibodies^® Powered by Atlas Antibodies
• 形狀: buffered aqueous glycerol solution
• 物種活性: human
• 加強驗證: RNAi knockdown; Learn more about Antibody Enhanced Validation
• 技術: immunoblotting: 0.04-0.4 μg/mL; immunofluorescence: 0.25-2 μg/mL; immunohistochemistry: 1:500-1:1000
• 免疫原序列: LKSEWQSMTQESFQESSVKELRRLEDQLAGLQQELAALALKQSSVAEEVGLLPQQIQAVRDDVESQFPAWISQFLARGGGGRVGLLQREEMQAQLRELESKILTHVAEMQGKSAREAAASLSLTLQKEGVIGVTEEQVHHIVKQALQRYSE
• 運輸包裝: wet ice
• 儲存溫度: −20°C
• 目標翻譯後修改: unmodified
• 基因資訊: human ... UNC84B(25777)

说明

一般說明

SUN2 (Sad1 and UNC84 domain containing 2) gene encodes a 85kDa inner nuclear membrane protein with the SUN domain localized to the periplasmic space between the inner and the outer nuclear membranes. It forms a bridge or a LINC complex across the nuclear envelope (NE) connecting NE to the cytoskeleton contributing to nuclear positioning and cellular rigidity. The N-terminus extends into the nucleoplasm. The C-terminal SUN domain that is in the perinuclear space associates with short, lumenal peptides of KASH domain containing membrane proteins of the outer nuclear membrane (ONM) to form a molecular link between the ONM and the inner nuclear membrane (INM).

SUN2 protein is a member of the linker of the nucleoskeleton and cytoskeleton complex. The SUN2 gene is mapped on the human chromosome at 22q13.1.

免疫原

Sad1/unc-84-like protein 2 recombinant protein epitope signature tag (PrEST)

應用

All Prestige Antibodies Powered by Atlas Antibodies are developed and validated by the Human Protein Atlas (HPA) project and as a result, are supported by the most extensive characterization in the industry.

The Human Protein Atlas project can be subdivided into three efforts: Human Tissue Atlas, Cancer Atlas, and Human Cell Atlas. The antibodies that have been generated in support of the Tissue and Cancer Atlas projects have been tested by immunohistochemistry against hundreds of normal and disease tissues and through the recent efforts of the Human Cell Atlas project, many have been characterized by immunofluorescence to map the human proteome not only at the tissue level but now at the subcellular level. These images and the collection of this vast data set can be viewed on the Human Protein Atlas (HPA) site by clicking on the Image Gallery link. We also provide Prestige Antibodies^® protocols and other useful information.

Anti-UNC84B antibody produced in rabbit, a Prestige Antibody, is developed and validated by the Human Protein Atlas (HPA) project . Each antibody is tested by immunohistochemistry against hundreds of normal and disease tissues. These images can be viewed on the Human Protein Atlas (HPA) site by clicking on the Image Gallery link. The antibodies are also tested using immunofluorescence and western blotting. To view these protocols and other useful information about Prestige Antibodies and the HPA, visit sigma.com/prestige.

生化／生理作用

Sad1 and UNC84 domain containing 2 (SUN2) acts as a tumor suppressor by inhibiting the expression of glucose transporter 1 (GLUT1) and lactate dehydrogenase A (LDHA) in lung cancer. Overexpression of the SUN2 gene leads to the inhibition of replication of the human immunodeficiency virus (HIV).

特點和優勢

Prestige Antibodies^® are highly characterized and extensively validated antibodies with the added benefit of all available characterization data for each target being accessible via the Human Protein Atlas portal linked just below the product name at the top of this page. The uniqueness and low cross-reactivity of the Prestige Antibodies^® to other proteins are due to a thorough selection of antigen regions, affinity purification, and stringent selection. Prestige antigen controls are available for every corresponding Prestige Antibody and can be found in the linkage section.

Every Prestige Antibody is tested in the following ways:

• IHC tissue array of 44 normal human tissues and 20 of the most common cancer type tissues.
• Protein array of 364 human recombinant protein fragments.

聯結

Corresponding Antigen APREST73388

外觀

Solution in phosphate-buffered saline, pH 7.2, containing 40% glycerol and 0.02% sodium azide

法律資訊

Prestige Antibodies is a registered trademark of Merck KGaA, Darmstadt, Germany

免責聲明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

安全信息

• 儲存類別代碼: 10 - Combustible liquids
• 水污染物質分類（WGK）: WGK 1
• 個人防護裝備: Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)