H4632

Hemoglobin 马

lyophilized powder

• 别名: Hb
• CAS号: 9047-09-0
• MDL號碼: MFCD00131282
• 分類程式碼代碼: 12352202
• NACRES: NA.61

属性

• 生物源: horse
• 形狀: lyophilized powder
• 技術: protein quantification: suitable
• 溶解度: H₂O: soluble 10 mg/mL
• UniProt登錄號: P01958; P02062
• 儲存溫度: 2-8°C
• 基因資訊: horse ... HBA(100036557) , HBB(100054109)

说明

一般說明

Hemoglobin is the major component of red blood cells and is responsible for their red color. Its normal concentration in erythrocytes is 34%. The structure of horse hemoglobin was elucidated first. It comprises heme (iron protoporphyrin IX group) and four polypeptide chains. The fetal and adult hemoglobin of horse are structurally identical.

應用

Hemoglobin equine has been used as a standard protein:

• to test solid-film sampling methodology in Fourier transform infrared spectroscopy (FT-IR) for protein secondary structure determination
• in capillary reversed-phase liquid chromatography-tandem mass spectrometry (LC/MS/MS) post enzymatic digestion
• for quantification of hemoglobin content from the planktonic crustacean, Daphnia magna

生化／生理作用

Hemoglobin is the most important respiratory protein of vertebrates by its ability to transport oxygen from the lungs to body tissues and to facilitate the return transport of carbon dioxide. The ferrous-ferric (Fe²⁺/Fe³⁺) balance is a physiological indicator of blood oxygenation. Deoxygenated hemoglobin accessorizes a feedback loop by reducing nitrite to nitric oxide (NO), a vasodilator which enhances blood flow to oxygen-deprived tissues. The fetal and adult hemoglobin from horse display differences in their affinity towards 2,3-diphosphoglycerate (2,3-DPG). Mutation in the globin gene is implicated in sickle cell anemia.

Oxygen transporter, NO scavenger

注意

Since native hemoglobin is readily oxidized in air, these preparations may be predominantly methemoglobin.

安全信息

• 儲存類別代碼: 11 - Combustible Solids
• 水污染物質分類（WGK）: WGK 3
• 閃點（°F）: Not applicable
• 閃點（°C）: Not applicable
• 個人防護裝備: Eyeshields, Gloves, type N95 (US)