推荐产品
生物源
chicken
品質等級
共軛
unconjugated
抗體表格
affinity isolated antibody
抗體產品種類
primary antibodies
無性繁殖
polyclonal
形狀
buffered aqueous solution
物種活性
human
製造商／商標名
Genway 15-288-21255B
技術
western blot: suitable
NCBI登錄號
UniProt登錄號
運輸包裝
wet ice
儲存溫度
−20°C
目標翻譯後修改
unmodified
基因資訊
human ... XPOT(11260)
一般說明
XPOT (exportin T) is a tRNA nuclear export receptor found in vertebrates. This protein shuttles between the cytoplasm and nucleus. It belongs to the importin-β family, and has a distant relation to Los1p protein found in yeast.
應用
Anti-Exportin T antibody produced in chicken is suitable for western blotting analysis at a dilution of 1:500, for tissue or cell staining at a dilution of 1:200.
生化／生理作用
Exportin-T acts as a specific mediator of tRNA export. Exportin-T is a RanGTP-binding, importin β-related factor with predominantly nuclear localization that shuttles rapidly between nucleus and cytoplasm. It interacts with nuclear pore complexes as well. Exportin-t binds tRNA directly and with high affinity. It is responsible for majority of tRNA export in cells and plays an essential role in the transport of tRNA. It is associated with intracellular tRNA trafficking and is in turn associated with discrete changes in the composition of cellular cytoplasmic multi-protein complexes containing tRNA.
外觀
Solution in phosphate buffered saline containing 0.02% sodium azide.
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儲存類別代碼
10 - Combustible liquids
水污染物質分類（WGK）
WGK 1
閃點（°F）
Not applicable
閃點（°C）
Not applicable
個人防護裝備
Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)
1,25-Dihydroxyvitamin D3 suppresses exportin expression in human promyelocytic leukemia HL-60 cells.
Takuji Suzuki et al.
Biomedical research (Tokyo, Japan), 27(2), 89-92 (2006-05-19)
The active form of vitamin D3, 1alpha,25-dihydroxyvitamin D3 (DVD), is a potent inducer of cell differentiation and inhibits proliferation of cells such as human promyelocytic leukemia HL-60 cells. In the present study, we examined the effects of DVD on the
C Kruse et al.
The Biochemical journal, 346 Pt 1, 107-115 (2000-02-05)
Vigilin is a ubiquitous multi heterogeneous nuclear ribonucleoprotein (hnRNP) K homologous (KH)-domain protein. Here we demonstrate that purified recombinant human vigilin binds tRNA molecules with high affinity, although with limited specificity. Nuclear microinjection experiments revealed for the first time that
U Kutay et al.
Molecular cell, 1(3), 359-369 (1998-07-14)
In eukaryotes, tRNAs are synthesized in the nucleus and after several maturation steps exported to the cytoplasm. Here, we identify exportin-t as a specific mediator of tRNA export. It is a RanGTP-binding, importin beta-related factor with predominantly nuclear localization. It
G J Arts et al.
The EMBO journal, 17(24), 7430-7441 (1998-12-19)
Exportin-t (Xpo-t) is a vertebrate nuclear export receptor for tRNAs that binds tRNA cooperatively with GTP-loaded Ran. Xpo-t antibodies are shown to efficiently block tRNA export from Xenopus oocyte nuclei suggesting that it is responsible for at least the majority
G J Arts et al.
Current biology : CB, 8(6), 305-314 (1998-03-25)
Transport of macromolecules between the nucleus and cytoplasm of eukaryotic cells is mediated by nuclear import and export receptors. The receptors identified to date are members of a family of Ran GTPase-binding proteins whose founding member is importin-beta. Interaction between
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