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一般說明
IL-8 (interleukin-8), also called CXCL8, is an α chemokine belonging to the cysteine-x-cysteine (CXC) chemokine subfamily. It is a pro-inflammatory cytokine and is secreted by multiple types of tissues and blood cells such as, monocytes, neutrophils, tissue macrophages, T-lymphocytes, endothelial and epithelial cells, and fibroblasts. It is pro-angiogenic and tumorigenic, and is produced by cancer cells such as, colorectal cancer cells.
應用
Anti-Interleukin-8 antibody produced in chicken is suitable for indirect ELISA and western blotting analysis at a dilution of 1:500, for tissue or cell staining at a dilution of 1:200.
生化／生理作用
Interleukin-8 (IL 8) is a proinflammatory chemokine that activates multiple signaling pathways. The exosomes released from chronic myelogenous leukemia (CML) cells stimulate bone marrow stromal cells to produce IL 8. It plays a very important regulatory function in tumorigenesis. Its polymorphism is associated with a significantly increased risk of cancers and may be useful for cancer susceptibility studies.
外觀
Solution in phosphate buffered saline containing 0.02% sodium azide.
免責聲明
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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儲存類別代碼
10 - Combustible liquids
水污染物質分類（WGK）
WGK 1
閃點（°F）
Not applicable
閃點（°C）
Not applicable
個人防護裝備
Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)
Maria Bălăşoiu et al.
Romanian journal of morphology and embryology = Revue roumaine de morphologie et embryologie, 55(2 Suppl), 575-578 (2014-09-03)
Colorectal cancer represents a major cause of mortality and morbidity and occupies the third place as cancer incidence and the fourth place as cancer mortality. Colorectal cancer causes 608 000 deaths per year, despite correct applied treatment (surgery and chemotherapy).
Chiara Corrado et al.
Cancer letters, 348(1-2), 71-76 (2014-03-25)
Chronic myelogenous leukemia (CML) is a myeloproliferative disorder characterized by the Bcr-Abl oncoprotein with constitutive tyrosine kinase activity. Exosomes are nanovesicles released by cancer cells that are involved in cell-to-cell communication thus potentially affecting cancer progression. It is well known
Ziliang Wang et al.
Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine, 35(7), 7115-7123 (2014-04-25)
Emerging evidences show that interleukin-8 (IL-8) has important regulatory functions in tumorigenesis. IL-8 -251A/T is a single nucleotide polymorphism in the promoter region of the IL-8 gene and affects IL-8 production. Analysis of previous studies on the association of -251A/T
Kai Yang et al.
International journal of molecular sciences, 15(11), 21286-21298 (2014-11-20)
The objective of this study was to analyze the expression levels of IL-8 in serum and liver tissues from patients with chronic hepatitis B (CHB) infection and to investigate whether IL-8 may antagonize interferon-alpha (IFN-α) antiviral activity against HBV. IL-8
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