推荐产品
生物源
chicken
共軛
unconjugated
抗體表格
affinity isolated antibody
抗體產品種類
primary antibodies
無性繁殖
polyclonal
形狀
buffered aqueous solution
物種活性
rat, mouse, human
製造商／商標名
Genway 15-288-20031F
技術
western blot: suitable
NCBI登錄號
UniProt登錄號
運輸包裝
wet ice
儲存溫度
−20°C
目標翻譯後修改
unmodified
基因資訊
human ... LEP(3952)
應用
Anti-Leptin antibody produced in chicken has been used for the immunohistochemistry study of mouse embryo and ovum. It is suitable for western blotting at a working dilution of 1:500 and for cell staining at a working dilution of 1:200.
生化／生理作用
LEP (leptin) encoded protein plays a key role in the regulation of body weight. It is secreted by white adipocytes. It has a key role in regulating the signaling pathway that can inhibit food intake and/or control energy expenditure to maintain constancy of the adipose mass. It is also involved in the regulation of immune and inflammatory responses, hematopoiesis, angiogenesis and wound healing. Defects in this gene can cause a rare disease characterized by low levels of serum leptin, severe hyperphagia and severe obesity, and morbid obesity with hypogonadism.
外觀
Solution in phosphate buffered saline containing 0.02% sodium azide.
免責聲明
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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儲存類別代碼
10 - Combustible liquids
水污染物質分類（WGK）
WGK 1
閃點（°F）
Not applicable
閃點（°C）
Not applicable
個人防護裝備
Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)
F F Chehab
Trends in pharmacological sciences, 21(8), 309-314 (2000-08-05)
Leptin, an adipocyte-derived hormone, informs neuroendocrine pathways about the status of energy stores in adipose tissue. The integration of this peripheral signal in hypothalamic networks results in activation of peripheral metabolic pathways that control energy build-up and expenditure. Firing of
Laura C Schulz et al.
Reproduction (Cambridge, England), 141(6), 767-777 (2011-03-30)
The hormone leptin, which is primarily produced by adipose tissue, is a critical permissive factor for multiple reproductive events in the mouse, including implantation. In the CD1 strain, maternally derived leptin from the oocyte becomes differentially distributed among the blastomeres
N Patel et al.
The Journal of biological chemistry, 274(32), 22729-22738 (1999-07-31)
We report the expression cloning of a novel leptin-binding protein of the immunoglobulin superfamily (OB-BP1) and a cross-hybridizing clone (OB-BP2) that is identical to a recently described sialic acid-binding I-type lectin called Siglec-5. Comparisons to other known Siglec family members
A leptin missense mutation associated with hypogonadism and morbid obesity.
A Strobel et al.
Nature genetics, 18(3), 213-215 (1998-03-21)
G M Lord et al.
Nature, 394(6696), 897-901 (1998-09-11)
Nutritional deprivation suppresses immune function. The cloning of the obese gene and identification of its protein product leptin has provided fundamental insight into the hypothalamic regulation of body weight. Circulating levels of this adipocyte-derived hormone are proportional to fat mass
我们的科学家团队拥有各种研究领域经验，包括生命科学、材料科学、化学合成、色谱、分析及许多其他领域.
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