推荐产品
一般說明
Research area: Cell signaling. Glutathione Reductase belongs to the homodimericFAD−disulfide oxidoreductases family. is made up of highly conserved domains such as two Rossmann fold domains, where one binds to reduced nicotinamide adenine dinucleotide phosphate (NADPH) and flavin adenine dinucleotide (FAD) the second one is an interface dimerization domain. It favors its accumulation in the regions of high electron flux in cells where reactive species are generated.
應用
人谷胱甘肽还原酶已被用于：
- 谷胱甘肽还原酶活性测定
- 氧化强制降解分析
- 氧化还原试验
生化／生理作用
谷胱甘肽还原酶是一种同源二聚体酶，每个亚基含有 1 个 FAD 分子和 1 个 NADPH 结合域。 人 GR (hGR) 和 恶性疟原虫 GR (PfGR) 对于疟原虫在人红细胞内的生存是必需的。因此，这种酶可用于候选抗疟疾试剂的研究。
谷胱甘肽还原酶是一种普遍存在的黄酶，参与细胞应激的保护。谷胱甘肽还原酶催化氧化型谷胱甘肽 (GSSG) 还原成谷胱甘肽 (GSH)。对维持足够水平的还原型细胞 GSH（作为与自由基和有机过氧化物反应的抗氧化剂）的谷胱甘肽氧化还原循环至关重要。谷胱甘肽还是谷胱甘肽过氧化物酶的电子供体，也是谷胱甘肽 S-转移酶的底物，有助于解毒和消除有毒亲电代谢物和外源性物质。
Human glutathione reductase is suitable as cytostatic and antimalarialagent. It may also be used to protect against malaria by mimicking favism by blockingthe enzyme with specific inhibitors.
單位定義
在 pH 7.5、25°C 下 1 个单位将还原 1.0μmol DTNB/min
外觀
含 25 mM Tris-HCl (pH 7.4)、1 mM EDTA 和 50% (v/v) 甘油的溶液。
免責聲明
除非我们的目录或产品随附的其他公司文件中另有说明，否则我们的产品预期仅供研究使用，不得用于任何其他目的，包括但不限于未经授权的商业用途、 体外 诊断用途、 离体 或 体内 治疗用途或任何类型的消费或人类或动物应用。
儲存類別代碼
10 - Combustible liquids
水污染物質分類（WGK）
WGK 2
閃點（°F）
Not applicable
閃點（°C）
Not applicable
個人防護裝備
Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)
其他客户在看
Haitao Shi et al.
Plant physiology and biochemistry : PPB, 71, 226-234 (2013-08-27)
As a gaseous molecule, hydrogen sulfide (H2S) has been recently found to be involved in plant responses to multiple abiotic stress. In this study, salt (150 and 300 mM NaCl), osmotic (15% and 30% PEG6000) and cold (4 °C) stress
Marcela Z Campanini et al.
Journal of photochemistry and photobiology. B, Biology, 127, 153-160 (2013-09-18)
Plants rich in antioxidant substances may be a promising strategy for preventing UV-induced oxidative and inflammatory damage of the skin. Pimenta pseudocaryophyllus is native to Brazil and presents flavonoids and other polyphenolic compounds in high concentration. Thus, the present study
Dietary methionine can sustain cytosolic redox homeostasis in the mouse liver
Sofi Eriksson, et al.
Nature Communications (2014)
C C Bohme et al.
The Journal of biological chemistry, 275(48), 37317-37323 (2000-09-02)
The homodimeric flavoenzyme glutathione reductase (GR) maintains high intracellular concentrations of the antioxidant glutathione (GSSG + NADPH + H(+) <--> 2 GSH + NADP(+)). Due to its central function in cellular redox metabolism, inhibition of GR from the malarial parasite
Walid Abu El-Soud et al.
Plant physiology and biochemistry : PPB, 71, 173-183 (2013-08-14)
Seed germination and growth of seedlings are critical phases of plant life that are adversely affected by various environmental cues. Water availability is one of the main factors that limit the productivity of many crops. This study was conducted to
我们的科学家团队拥有各种研究领域经验，包括生命科学、材料科学、化学合成、色谱、分析及许多其他领域.
联系技术服务部门