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Merck
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文件

G6776

Sigma-Aldrich

染料木黄酮

from Glycine max (soybean), ~98% (HPLC)

别名:

4′,5,7-三羟基异黄酮, 5,7-二羟基-3-（4-羟基苯基）-4H-1-苯并吡喃-4-酮

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About This Item

经验公式（希尔记法）:
C15H10O5
CAS号:
446-72-0
分子量:
270.24
Beilstein:
263823
EC號碼:
207-174-9
MDL號碼:
MFCD00016952
分類程式碼代碼:
12352200
PubChem物質ID:
24895273
NACRES:
NA.77

生物源

Glycine max (soybean)

品質等級

200

化驗

~98% (HPLC)

形狀

powder

mp

>280 °C

溶解度

DMSO: soluble
ethanol: soluble

儲存溫度

−20°C

SMILES 字串

Oc1ccc(cc1)C2=COc3cc(O)cc(O)c3C2=O

InChI

1S/C15H10O5/c16-9-3-1-8(2-4-9)11-7-20-13-6-10(17)5-12(18)14(13)15(11)19/h1-7,16-18H

InChI 密鑰

TZBJGXHYKVUXJN-UHFFFAOYSA-N

基因資訊

human ... AKT1(207) , CYP19A1(1588) , EGFR(1956) , ESR1(2099) , ESR2(2100)
mouse ... Esr1(13982) , Hexa(15211)
rat ... Adora1(29290) , Adora2a(25369) , Ar(24208)

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一般說明

金雀异黄素是来自大豆的异黄酮营养保健品，同时也是一种植物雌激素。它来源于染料木苷。

應用

金雀异黄素已被用作：
  • 作为抗癌剂用于测试其在宫颈腺癌细胞中的细胞毒性
  • 作为多酚用于测试其对精子线粒体中活性氧的作用
  • 测试其对紫外照射下皮肤和瘢痕疙瘩成纤维细胞的自由基清除作用

生化／生理作用

金雀异黄素具有抗氧化功能，并可有效淬灭活性氧。它有益于人体健康。
酪氨酸蛋白激酶抑制剂; 在其他蛋白激酶反应中，ATP的竞争性抑制剂。 抗血管生成剂，可下调参与控制血管生成的基因的转录。

特點和優勢

该化合物是《受体分类及信号转导手册》上Met页面上的特色化合物。想要浏览手册的其他页面， 请单击此处。

象形圖

Exclamation mark
GHS07

訊號詞

Warning

危險聲明

H302

危險分類

Acute Tox. 4 Oral

儲存類別代碼

11 - Combustible Solids

水污染物質分類（WGK）

WGK 3

閃點（°F）

Not applicable

閃點（°C）

Not applicable

個人防護裝備

Eyeshields, Faceshields, Gloves, type N95 (US)

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Haolong Li et al.
Oncotarget, 6(24), 20474-20484 (2015-05-27)
Although the new generation of androgen receptor (AR) antagonists like enzalutamide (ENZ) prolong survival of metastatic castration-resistant prostate cancer (CRPC), AR-driven tumors eventually recur indicating that additional therapies are required to fully block AR function. Since DNA topoisomerase II (Topo
Vivek Barve et al.
Journal of medicinal chemistry, 49(13), 3800-3808 (2006-06-23)
The synthesis and characterization of Schiff base derivatives of 3-formylchromone 3-6 (FPA-120 to FPA-123), the minimal biologically active structural motif of soy isoflavone, genistein, and their copper(II) complexes 7-10 (FPA-124 to FPA-127) are reported here. These copper complexes possess distorted
Darren M Hutt et al.
Nature chemical biology, 6(1), 25-33 (2009-12-08)
Chemical modulation of histone deacetylase (HDAC) activity by HDAC inhibitors (HDACi) is an increasingly important approach for modifying the etiology of human disease. Loss-of-function diseases arise as a consequence of protein misfolding and degradation, which lead to system failures. The
J W Lampe et al.
The American journal of clinical nutrition, 60(1), 122-128 (1994-07-01)
Lignans and isoflavonoid phytoestrogens, produced from plant precursors by colonic bacteria, may protect against certain cancers. We examined the effects of flaxseed consumption on urinary lignans and isoflavonoids. Eighteen women consumed their usual omnivorous diets for three menstrual cycles and
Selin Bolca et al.
The American journal of clinical nutrition, 91(4), 976-984 (2010-02-19)
Despite decades of research on the relation between soy and breast cancer, questions regarding the absorption, metabolism, and distribution of isoflavones in breast tissue largely remain unanswered. We evaluated the potential health effects of isoflavone consumption on normal breast tissue;
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