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化驗
≥97% (HPLC)
儲存溫度
−20°C
SMILES 字串
NCC(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCNC(N)=N)C(=O)N2CCC[C@H]2C(N)=O
InChI
1S/C18H32N8O4/c19-10-14(27)25-8-3-6-13(25)16(29)24-11(4-1-7-23-18(21)22)17(30)26-9-2-5-12(26)15(20)28/h11-13H,1-10,19H2,(H2,20,28)(H,24,29)(H4,21,22,23)/t11-,12-,13-/m0/s1
InChI 密鑰
SCCTZYGEMPQRCV-AVGNSLFASA-N
基因資訊
human ... FN1(2335)
mouse ... FN1(14268)
rat ... FN1(25661)
Amino Acid Sequence
Gly-Pro-Arg-Pro-NH2
一般說明
Gly-Pro-Arg-Pro 是一种模拟纤维蛋白 a 链中 N-末端 Gly-Pro-Arg 区域的肽。
應用
氨基丙酸被用于
- 作为液相和结合凝血酶抑制试验中缓冲液的成分，测定在制备人可溶性纤维蛋白过程中小鼠血液中存在 α-凝血酶时，
- 用于阻断纤维蛋白聚合和防止纤维蛋白凝块形成的凝血酶活性，
- 以阻断可溶性纤维蛋白的聚合
生化／生理作用
Gly-Pro-Arg-Pro肽能够抑制纤维蛋白聚合的早期阶段。即使是存在EGTA（乙二醇-双（β-氨基乙基醚）-N,N,N', N' 四乙酸）的情况下，该肽的酰胺衍生物也能抑制纤溶酶对纤维蛋白原和片段D的降解。
包裝
无底玻璃瓶。内含物装在插入的融合锥内。
儲存類別代碼
11 - Combustible Solids
水污染物質分類（WGK）
WGK 3
閃點（°F）
Not applicable
閃點（°C）
Not applicable
個人防護裝備
Eyeshields, Gloves, type N95 (US)
P Klement et al.
Journal of thrombosis and haemostasis : JTH, 1(3), 587-594 (2003-07-23)
Although hirudin is better than heparin at preventing recurrent ischemia in patients with unstable angina, hirudin produces more bleeding. The purpose of this study was to use a rabbit arterial thrombosis prevention and ear bleeding model to determine whether for
P C Liaw et al.
The Journal of biological chemistry, 276(24), 20959-20965 (2001-04-11)
Although fibrin-bound thrombin is resistant to inactivation by heparin.antithrombin and heparin.heparin cofactor II complexes, indirect studies in plasma systems suggest that the dermatan sulfate.heparin cofactor II complex can inhibit fibrin-bound thrombin. Herein we demonstrate that fibrin monomer produces a 240-fold
K Kawasaki et al.
Chemical & pharmaceutical bulletin, 40(12), 3253-3260 (1992-12-01)
N-Terminal tetrapeptide analogs of fibrin alpha-chain were synthesized by the solution method using a new active ester, the ester of the oxime of p-nitroacetophenone, and by the solid-phase method. Their inhibitory effects on fibrinogen/thrombin clotting were examined. Of the synthetic
Leonardo Pasalic et al.
Methods in molecular biology (Clifton, N.J.), 1646, 369-389 (2017-08-15)
Flow cytometry is a powerful tool for rapid evaluation of multiple functional properties of large numbers of platelets in whole blood. In the following chapter, we provide a number of flow cytometry-based protocols broadly aimed at (1) assessment of constitutively
Moon J Cho et al.
Blood, 99(7), 2442-2447 (2002-03-16)
Members of the Src family of kinases are abundant in platelets. Although their localization is known, their role(s) in platelet function are not well understood. Lyn is a Src-family kinase that participates in signal transduction pathways elicited by collagen-related peptide;
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