G3545

GW583340 dihydrochloride

≥97% (HPLC), solid

• 别名: 4-[3-Chloro-4-[(3-fluorophenyl)methoxy]phenylamino]-6-[2-[[2-(methylsulfonyl)ethyl]aminomethyl]-4-thiazolyl]quinazoline dihydrochloride
• 经验公式（希尔记法）: C₂₈H₂₅ClFN₅O₃S₂ · 2HCl
• CAS号: 1173023-85-2
• 分子量: 671.03
• MDL號碼: MFCD07370137
• 分類程式碼代碼: 51111800
• PubChem物質ID: 24895131
• NACRES: NA.77

属性

• 品質等級: 100
• 化驗: ≥97% (HPLC)
• 形狀: solid
• mp: 259.8-262.4 °C (lit.)
• 溶解度: DMSO: 9 mg/mL
• 起源: GlaxoSmithKline
• 儲存溫度: 2-8°C
• SMILES 字串: Cl[H].Cl[H].CS(=O)(=O)CCNCc1nc(cs1)-c2ccc3ncnc(Nc4ccc(OCc5cccc(F)c5)c(Cl)c4)c3c2
• InChI: 1S/C28H25ClFN5O3S2.2ClH/c1-40(36,37)10-9-31-14-27-35-25(16-39-27)19-5-7-24-22(12-19)28(33-17-32-24)34-21-6-8-26(23(29)13-21)38-15-18-3-2-4-20(30)11-18;;/h2-8,11-13,16-17,31H,9-10,14-15H2,1H3,(H,32,33,34);2*1H
• InChI 密鑰: WIMITXDBYLKRKB-UHFFFAOYSA-N

说明

生化／生理作用

Potent dual ErbB-2/EGFR tyrosine kinase inhibitor. IC₅₀= 0.01 and 0.014 μM for EGFR and ErbB-2. Orally active.

特點和優勢

This compound is a featured product for Kinase Phosphatase Biology research. Click here to discover more featured Kinase Phosphatase Biology products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

This compound was developed by GlaxoSmithKline. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

法律資訊

Sold for research purposes under agreement from Glaxo­Smith­Kline

安全信息

• 象形圖: GHS07
• 訊號詞: Warning
• 危險聲明: H315,H319,H335
• 防範說明: P261 - P264 - P271 - P280 - P302 + P352 - P305 + P351 + P338
• 危險分類: Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
• 標靶器官: Respiratory system
• 儲存類別代碼: 11 - Combustible Solids
• 水污染物質分類（WGK）: WGK 3
• 閃點（°F）: Not applicable
• 閃點（°C）: Not applicable
• 個人防護裝備: dust mask type N95 (US), Eyeshields, Gloves