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Merck

G2253

Sigma-Aldrich

L-谷氨酸& # 947;-单羟基己酸酯

≥97% (TLC)

别名:

-5--羟基谷氨酰胺, L-& # 947;-谷氨酰异羟肟酸

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About This Item

经验公式(希尔记法):
C5H10N2O4
CAS号:
分子量:
162.14
MDL號碼:
分類程式碼代碼:
12352209
PubChem物質ID:
NACRES:
NA.26

产品名称

L-谷氨酸& # 947;-单羟基己酸酯,

化驗

≥97% (TLC)

品質等級

形狀

powder

顏色

white to off-white

應用

detection

儲存溫度

−20°C

SMILES 字串

NC(CCC(=O)NO)C(O)=O

InChI

1S/C5H10N2O4/c6-3(5(9)10)1-2-4(8)7-11/h3,11H,1-2,6H2,(H,7,8)(H,9,10)

InChI 密鑰

YVGZXTQJQNXIAU-UHFFFAOYSA-N

應用

左旋谷氨酸γ-单异羟肟酸已用作计算谷氨酰胺转胺酶(TGase)活性的标准品。

生化/生理作用

L-谷氨酸& # 947;-单羟基肟酸盐[L-谷氨酸(γ)HXM]用作钒配体,增强钒代谢活性。L-Glu(γ)HXM也用作大肠杆菌 大肠杆菌天冬酰胺合成酶B的底物和作为ATP依赖性的大肠杆菌γ-谷氨酰半胱氨酸合成酶的不可逆抑制剂。

儲存類別代碼

11 - Combustible Solids

水污染物質分類(WGK)

WGK 3

閃點(°F)

Not applicable

閃點(°C)

Not applicable

個人防護裝備

Eyeshields, Gloves, type N95 (US)


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分析证书(COA)

Lot/Batch Number

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M Katoh et al.
Bioscience, biotechnology, and biochemistry, 62(7), 1455-1457 (1998-08-28)
Incubation of Escherichia coli gamma-glutamylcysteine synthetase with L-glutamic acid gamma-monohydroxamate and ATP caused slow but irreversible inhibition of the enzyme, and more than 90% activity was lost in three days. The enzyme was not inactivated when ATP was absent or
N Seiler et al.
Neurochemical research, 15(3), 301-305 (1990-03-01)
The method for the assay of glutamine synthetase (GlnS) relies on the gamma-glutamyl transferase reaction, i.e. the formation of glutamyl-gamma-hydroxamate from glutamine and hydroxylamine, and the chromatographic separation of the reaction product from the reactants. The method is not only
X Huang et al.
The Journal of biological chemistry, 275(34), 26233-26240 (2000-08-22)
The x-ray crystal structure of the heterodimeric carbamoyl phosphate synthetase from Escherichia coli has identified an intermolecular tunnel that connects the glutamine binding site within the small amidotransferase subunit to the two phosphorylation sites within the large synthetase subunit. The
N Thomasset et al.
Anticancer research, 13(5A), 1393-1398 (1993-09-01)
We have previously shown that L-glutamic acid gamma-monohydroxamate (GAH) exhibits an antitumor activity, both in vitro and in vivo. In this report we explore the selective cytotoxicity of GAH in vitro by comparing the survival of tumor and normal cells.
C J Lusty
FEBS letters, 314(2), 135-138 (1992-12-14)
E. coli carbamyl phosphate synthetase binds 0.2-0.4 mol equivalents of glutamine in an acid resistant form. The bound material is quantitatively released as glutamate by weak base hydrolysis and as a mixture of 12% glutamate, 10% gamma-glutamylhydroxamate, and 70% pyrrollidonecarboxylic

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