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Merck
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Key Documents

F0681

Sigma-Aldrich

Factor V human

aqueous glycerol solution, ≥25 units/mg protein

别名:

Labile factor, Proaccelerin

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About This Item

MDL號碼:
分類程式碼代碼:
12352202
NACRES:
NA.61

生物源

human

品質等級

形狀

aqueous glycerol solution

比活性

≥25 units/mg protein

技術

ligand binding assay: suitable

UniProt登錄號

運輸包裝

wet ice

儲存溫度

−20°C

基因資訊

human ... F5(2153)

一般說明

Factor V is a single chain glycoprotein involved in the blood coagulation cascade. It is the procofactor of Va which accelerates the conversion of prothrombin to thrombin.

應用

Factor V is a key component in blood coagulation systems, where deficiencies can inhibit thrombin generation and affect hemostasis. It has been used in studies of Coagulopathic bleeding which occurs following injury and is a leading cause of in hospital deaths.

聯結

View this factors role in the Coagulation Cascade.

單位定義

One unit is equivalent to the Factor V activity in 1.0 mL of normal human plasma at pH 7.4 at 37 °C.

外觀

Aqueous solution containing 50% (v/v) glycerol

免責聲明

RESEARCH USE ONLY. This product is regulated in France when intended to be used for scientific purposes, including for import and export activities (Article L 1211-1 paragraph 2 of the Public Health Code). The purchaser (i.e. enduser) is required to obtain an import authorization from the France Ministry of Research referred in the Article L1245-5-1 II. of Public Health Code. By ordering this product, you are confirming that you have obtained the proper import authorization.

儲存類別代碼

10 - Combustible liquids

水污染物質分類(WGK)

WGK 2

閃點(°F)

Not applicable

閃點(°C)

Not applicable


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Sandro B Rizoli et al.
The Journal of trauma, 71(5 Suppl 1), S427-S434 (2011-12-17)
Coagulopathic bleeding is a leading cause of in-hospital death after injury. A recently proposed transfusion strategy calls for early and aggressive frozen plasma transfusion to bleeding trauma patients, thus addressing trauma-associated coagulopathy (TAC) by transfusing clotting factors (CFs). This strategy
Early coagulopathy in trauma patients: An on-scene and hospital admission study.
Floccard B., et al.
Injury (2010)

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