所有图片(1)
About This Item
经验公式（希尔记法）:
C15H12NFO3
CAS号:
分子量:
273.26
MDL號碼:
分類程式碼代碼:
12352203
PubChem物質ID:
NACRES:
NA.77
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品質等級
化驗
≥98% (HPLC)
形狀
solid
溶解度
DMSO: soluble 19 mg/mL
SMILES 字串
COC(=O)c1ccccc1NC(=O)c2ccc(F)cc2
InChI
1S/C15H12FNO3/c1-20-15(19)12-4-2-3-5-13(12)17-14(18)10-6-8-11(16)9-7-10/h2-9H,1H3,(H,17,18)
InChI 密鑰
KIAPWMKFHIKQOZ-UHFFFAOYSA-N
應用
Exo 1 已被用作 BRB80 缓冲液的组成成分，以被用于研究外壳蛋白 1 (COPI) 介导的膜运输。它也被用作高尔基体抑制剂来研究其对长散布的核元件 1 (L1) 逆转录转座的影响。
生化／生理作用
Exo 1 是一种可渗透细胞的邻氨基苯甲酸甲酯类似物，可促进二磷酸腺苷 (ADP)-核糖基化因子 (ARF) 1 从高尔基体膜释放。它还可抑制内质网 (ER) 和高尔基体之间的膜运输。
可逆的胞吐抑制剂； 高尔基体ARF 1（ADP-核糖基化因子）GTPase激活剂。
儲存類別代碼
11 - Combustible Solids
水污染物質分類（WGK）
WGK 3
閃點（°F）
Not applicable
閃點（°C）
Not applicable
個人防護裝備
Eyeshields, Gloves, type N95 (US)
其他客户在看
ALan F Rees et al.
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Megan Culbreth et al.
Frontiers in toxicology, 3, 803987-803987 (2022-03-18)
Studies in in vivo rodent models have been the accepted approach by regulatory agencies to evaluate potential developmental neurotoxicity (DNT) of chemicals for decades. These studies, however, are inefficient and cannot meet the demand for the thousands of chemicals that
Axel V Horn et al.
PLoS genetics, 13(6), e1006837-e1006837 (2017-06-07)
Long interspersed nuclear element-1s (LINE-1s, or L1s) are an active family of retrotransposable elements that continue to mutate mammalian genomes. Despite the large contribution of L1 to mammalian genome evolution, we do not know where active L1 particles (particles in
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