推荐产品
生物源
rat
共軛
unconjugated
抗體表格
purified from hybridoma cell culture
抗體產品種類
primary antibodies
無性繁殖
RCR-379, monoclonal
形狀
buffered aqueous solution
物種活性
human
技術
flow cytometry: 5-20 μg/mL using HUVEC cells
同型
IgG2a
UniProt登錄號
運輸包裝
dry ice
儲存溫度
−20°C
目標翻譯後修改
unmodified
基因資訊
human ... PROCR(10544)
相关类别
一般說明
Monoclonal Anti-endothelial cell protein C receptor (EPCR) (rat IgG2a isotype) is derived from the RCR379 hybridoma produced by the fusion of mouse SP2/0 myeloma cells and lymphatic cells isolated from the superficial inguinal lymph nodes from Wister rats immunized with human EPCR-positive RE-1 cells. Endothelial protein C receptor (EPCR), also known as activated protein C receptor (APC receptor), is a protein encoded by the PROCR gene in humans and is mapped to the locus 20q11.22. EPCR is a type 1 transmembrane glycoprotein containing two domains in the extracellular region that are homologous to the α1 and α2 domains of CD1/ major histocompatibility complex class 1 (MHC) class 1 molecules. It is expressed exclusively in endothelial cells and small vessels such as capillaries of the alveolar wall in the lung.
特異性
Monoclonal Anti-Endothelial Cell Protein C Receptor (EPCR) recognizes human EPCR (49 kDa).
免疫原
human EPCR-positive RE-1 cells.
應用
Monoclonal Anti-Endothelial Cell Protein C Receptor antibody produced in rat is suitable for flow cytometry at a concentration of 5-20μg/mL using HUVEC cells.
Monoclonal Anti-Endothelial Cell Protein C Receptor antibody produced in rat may be used in immunohistochemistry.
生化／生理作用
Endothelial protein C receptor (EPCR) also known as activated protein C receptor (APC receptor) is involved in regulation of the cytoprotective and anticoagulant pathways of protein C. EPCR is a member of the CD1/major histocompatibility complex superfamily and plays an important role in regulating the inflammatory response. It is also identified as an endothelial receptor for specific P. falciparum erythrocyte membrane protein 1 (PfEMP1) subtypes. EPCR is associated with an increased risk of venous thromboembolism (VTE).
The EPCR protein also performs other functions, like binding to proteinase. The complex then binds to macrophage 1 antigen (MAC-1) on activated neutrophils and inhibits their adhesion to activated endothelium
外觀
0.01M 磷酸缓冲盐溶液，pH 7.4，含 15mM 叠氮化钠。
儲存和穩定性
For continuous use, store at 2-8 °C for up to one month. For prolonged storage, freeze in working aliquots at −20 °C. Repeated freezing and thawing is not recom-mended. Storage in frost-free freezers is also not recommended. If slight turbidity occurs upon prolonged storage, clarify the solution by centrifugation before use. Working dilutions should be discarded if not used within 12 hours.
免責聲明
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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儲存類別代碼
10 - Combustible liquids
水污染物質分類（WGK）
WGK 2
閃點（°F）
Not applicable
閃點（°C）
Not applicable
個人防護裝備
Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)
Vaheh Oganesyan et al.
The Journal of biological chemistry, 277(28), 24851-24854 (2002-05-30)
The endothelial cell protein C receptor (EPCR) shares approximately 20% sequence identity with the major histocompatibility complex class 1/CD1 family of molecules, accelerates the thrombin-thrombomodulin-dependent generation of activated protein C, a natural anticoagulant, binds to activated neutrophils, and can undergo
Alice G Vassiliou et al.
Intensive care medicine, 39(10), 1752-1759 (2013-07-25)
Endothelial protein C receptor (EPCR) is expressed mainly in endothelial cells and is involved in regulation of the cytoprotective and anticoagulant pathways of protein C. We assessed whether haplotypes in the EPCR gene modify the risk of severe sepsis and/or
P Medina et al.
Arteriosclerosis, thrombosis, and vascular biology, 34(3), 684-690 (2014-01-18)
To confirm the effect of the endothelial protein receptor gene (PROCR) haplotypes H1 and H3 on venous thromboembolism (VTE), to study their effect on endothelial protein C receptor (EPCR) expression in human umbilical vein endothelial cells, and to investigate the
Izumi Naka et al.
Malaria journal, 13, 105-105 (2014-03-19)
Cytoadhesion of Plasmodium falciparum-infected erythrocytes to endothelial cells in microvessels is a remarkable characteristic of severe malaria. The endothelial protein C receptor (EPCR), encoded by the endothelial protein C receptor gene (PROCR), has recently been identified as an endothelial receptor
Z Laszik et al.
Circulation, 96(10), 3633-3640 (1997-12-13)
The protein C anticoagulant pathway is critical to the control of hemostasis. Thrombomodulin and a newly identified receptor for protein C/activated protein C, EPCR, are both present on endothelium. EPCR augments activation of protein C by the thrombin-thrombomodulin complex. To
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