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Merck

E6005

Sigma-Aldrich

乙硫磷酰胺

≥98.0%, suitable for ligand binding assays

别名:

2-乙基-4-吡啶羧基硫代酰胺

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About This Item

经验公式(希尔记法):
C8H10N2S
CAS号:
分子量:
166.24
EC號碼:
MDL號碼:
分類程式碼代碼:
12352111
PubChem物質ID:
NACRES:
NA.26

product name

乙硫磷酰胺,

化驗

≥98.0%

品質等級

形狀

powder

技術

ligand binding assay: suitable

顏色

yellow

儲存溫度

2-8°C

SMILES 字串

CCc1cc(ccn1)C(N)=S

InChI

1S/C8H10N2S/c1-2-7-5-6(8(9)11)3-4-10-7/h3-5H,2H2,1H3,(H2,9,11)

InChI 密鑰

AEOCXXJPGCBFJA-UHFFFAOYSA-N

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一般說明

乙硫异烟胺 (ETA,ETH) 是一种硫代酰胺 ,是一种抗结核药,在其他药物无效时,可作为二线治疗药物用于治疗结核病。 ETA 的结构与异烟肼相似。

應用

乙硫异烟胺用于抗菌剂 和测试化合物对 结核分枝杆菌的效价测定

生化/生理作用

乙硫异烟胺用作抗结核抗生素和甲状腺功能减退的诱导剂。

象形圖

Health hazardExclamation mark

訊號詞

Warning

危險聲明

危險分類

Acute Tox. 4 Oral - Repr. 2

儲存類別代碼

11 - Combustible Solids

水污染物質分類(WGK)

WGK 3

閃點(°F)

Not applicable

閃點(°C)

Not applicable

個人防護裝備

Eyeshields, Gloves, type P3 (EN 143) respirator cartridges


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Abhijeet Y Deshpande et al.
Biomedical chromatography : BMC, 25(9), 985-994 (2011-01-27)
A highly sensitive and specific LC-MS/MS method has been developed for simultaneous quantification of ethionamide and ethionamide sulfoxide in human plasma (300 µL) using prothionamide as an internal standard (IS). Solid-phase extraction was used to extract ethionamide, ethionamide sulfoxide and IS
Nuno Vale et al.
European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V, 81(2), 314-323 (2012-03-16)
Multidrug-resistant tuberculosis (MDR-TB) has become a worldwide problem and a major public health concern. The mechanisms of resistance are fairly well characterized for most agents, but MDR limits the therapeutic usefulness of both new and classical medicines against TB. Ethionamide
Ekaterina Gelman et al.
Antimicrobial agents and chemotherapy, 56(7), 3610-3614 (2012-04-25)
The genus Mycobacterium comprises slow-growing species with generation times ranging from hours to weeks. The protracted incubation time before colonies appear on solid culture medium can result in overgrowth by faster-growing microorganisms. To prevent contamination, the solid media used in
S Thee et al.
Tuberculosis (Edinburgh, Scotland), 97, 126-136 (2015-11-21)
Ethionamide (ETH) and prothionamide (PTH), both thioamides, have proven efficacy in clinical studies and form important components for multidrug-resistant tuberculosis treatment regimens and for treatment of tuberculous meningitis in adults and children. ETH and PTH are pro-drugs that, following enzymatic
Lack of cross-toxicity between isoniazid and ethionamide in severe cutaneous adverse drug reactions: a series of 25 consecutive confirmed cases.
Lehloenya RJ, et al.
The Journal of Antimicrobial Chemotherapy, 70(9), 2648-2651 (2015)

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