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化驗
≥98% (HPLC)
形狀
solid
儲存條件
desiccated
顏色
white
溶解度
H2O: 38 mg/mL
起源
Boehringer Ingelheim
儲存溫度
2-8°C
SMILES 字串
Cl[H].NC1=NCC2N1c3ccccc3Cc4ccccc24
InChI
1S/C16H15N3.ClH/c17-16-18-10-15-13-7-3-1-5-11(13)9-12-6-2-4-8-14(12)19(15)16;/h1-8,15H,9-10H2,(H2,17,18);1H
InChI 密鑰
VKXSGUIOOQPGAF-UHFFFAOYSA-N
基因資訊
human ... HRH1(3269)
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一般說明
Epinastine has antihistamine functions. In mast cells, it may modulate cytokine and chemokine production. In dendritic cells, it controls T helper cell mediated immune response. Epinastine hydrochloride does not traverse the brain barrier. Oral dosage of epinastine hydrochloride is prescribed for children with sleep-disordered breathing (SDB) and nasal inflammation. Ophthalmic solution of epinastine is effective for allergic conjunctivitis.
生化／生理作用
Epinastine hydrochloride is a non-sedating H1 histamine receptor antagonist.
特點和優勢
This compound is featured on the Histamine Receptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
This compound was developed by Boehringer Ingelheim. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.
訊號詞
Danger
危險聲明
危險分類
Acute Tox. 3 Oral
儲存類別代碼
6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
水污染物質分類（WGK）
WGK 3
閃點（°F）
Not applicable
閃點（°C）
Not applicable
個人防護裝備
Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges
Influence of epinastine hydrochloride, an H1-receptor antagonist, on the function of mite allergen-pulsed murine bone marrow-derived dendritic cells in vitro and in vivo
Oshima KZ, et al.
Mediators of Inflammation, 2009 (2009)
Population pharmacokinetics of epinastine, a histamine H1 receptor antagonist, in adults and children
Sarashina A, et al.
British Journal of Clinical Pharmacology, 59(1), 43-53 (2005)
The Effectiveness of Epinastine Hydrochloride for Pediatric Sleep-Disordered Breathing Related Symptoms Caused By Hyperesthetic Non-Infectious Rhinitis
Hara H, et al.
Otolaryngology, 4(150), 2-2 (2013)
Inhibition of angiogenic factor production from murine mast cells by an antiallergic agent (epinastine hydrochloride) in vitro
Asano K, et al.
Mediators of Inflammation, 2008 (2008)
Rosaly Vieira dos Santos et al.
Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology, 102(6), 495-499 (2009-06-30)
Nonsedating antihistamines (nsAHs) are recommended as first-line therapeutics for the treatment of mast cell-driven disorders, including allergic rhinitis and urticaria. However, their superiority over first-generation AHs (fgAHs) has recently been called into question, mainly because of the lack of supporting
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