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Merck

D9175

Sigma-Aldrich

硝苯呋海因 钠盐

别名:

1-[[[5-(4-硝基苯)-2-呋喃基]亚甲基氨基]-2,4-咪唑啉二酮 钠盐

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About This Item

经验公式(希尔记法):
C14H9N4NaO5
CAS号:
分子量:
336.23
MDL號碼:
分類程式碼代碼:
12352200
PubChem物質ID:
NACRES:
NA.77

形狀

solid

品質等級

起源

JHP Pharmaceuticals

SMILES 字串

[Na+].[H]\C(=N/N1CC(=O)N=C1[O-])c2ccc(o2)-c3ccc(cc3)[N+]([O-])=O

InChI

1S/C14H10N4O5.Na/c19-13-8-17(14(20)16-13)15-7-11-5-6-12(23-11)9-1-3-10(4-2-9)18(21)22;/h1-7H,8H2,(H,16,19,20);/q;+1/p-1/b15-7+;

InChI 密鑰

KSRLIXGNPXAZHD-HAZZGOGXSA-M

基因資訊

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生化/生理作用

肌浆网 Ca2+ 释放的抑制剂;肌肉松弛剂。

特點和優勢

《受体分类和信号转导》手册的 InsP3/Ryanodine 受体页有该化合物的介绍。想要浏览手册的其他页面, 请单击此处
该化合物由JHP Pharmaceuticals开发。要浏览其他药物开发化合物和批准的药物/候选药物列表,单击此处

儲存類別代碼

11 - Combustible Solids

水污染物質分類(WGK)

WGK 2

閃點(°F)

Not applicable

閃點(°C)

Not applicable


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Eshwar Reddy Tammineni et al.
Virology, 553, 81-93 (2020-11-30)
Dengue virus (DENV) infection elevates intracellular Ca2+ concentration ([Ca2+]i), but it is unknown whether Ca2+ and calmodulin (CaM) are involved in DENV infection. We conducted immunofluorescence and western blot experiments and measured [Ca2+]i examining the effects of DENV infection and
Beth A McNally et al.
Frontiers in physiology, 12, 737291-737291 (2021-10-16)
Daily regulation of Ca2+ - and voltage-activated BK K+ channel activity is required for action potential rhythmicity in the suprachiasmatic nucleus (SCN) of the hypothalamus, the brain's circadian clock. In SCN neurons, BK activation is dependent upon multiple types of
G Haskó et al.
British journal of pharmacology, 124(6), 1099-1106 (1998-08-28)
1. Intracellular calcium has been suggested to be an important mediator of the cellular response in endotoxaemia and shock. Dantrolene is an agent that interferes with intracellular calcium fluxes resulting in a decreased availability of calcium in the cytoplasm. Here
Mohammed Ali Azam et al.
Heart rhythm O2, 2(6Part B), 733-741 (2022-01-07)
Doxorubicin (Dox) is a potent chemotherapeutic agent, but its usage is limited by dose-dependent cardiotoxicity. Intracellular calcium dysregulation has been reported to be involved in doxorubicin-induced cardiomyopathy (DICM). The cardioprotective role of RyR stabilizer dantrolene (Dan) on the calcium dynamics
Jiao Liu et al.
Frontiers in pharmacology, 13, 882198-882198 (2022-05-07)
Diabetic cardiomyopathy (DCM) is a serious complication of diabetes that can lead to heart failure and death, for which there is no effective treatment. Rhynchophylline (Rhy) is the main effective component of the Chinese herbal medicine Uncaria rhynchophylla, which mainly

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