所有图片(1)
About This Item
经验公式（希尔记法）:
C11H14ClNO3
CAS号:
分子量:
243.69
MDL號碼:
分類程式碼代碼:
12352200
PubChem物質ID:
NACRES:
NA.77
化驗
≥98% (HPLC)
形狀
powder
顏色
white to off-white
溶解度
DMSO: ≥20 mg/mL
儲存溫度
2-8°C
SMILES 字串
Cc1cc(Cl)ccc1OCCCC(=O)NO
InChI
1S/C11H14ClNO3/c1-8-7-9(12)4-5-10(8)16-6-2-3-11(14)13-15/h4-5,7,15H,2-3,6H2,1H3,(H,13,14)
InChI 密鑰
JHSXDAWGLCZYSM-UHFFFAOYSA-N
生化／生理作用
Droxinostat is a selective inhibitor of HDAC3, HDAC6, and HDAC8.
特點和優勢
This compound is a featured product for Gene Regulation research. Click here to discover more featured Gene Regulation products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.
訊號詞
Danger
危險分類
Acute Tox. 4 Oral - Eye Dam. 1 - Skin Irrit. 2 - STOT SE 3
儲存類別代碼
11 - Combustible Solids
水污染物質分類（WGK）
WGK 3
閃點（°F）
Not applicable
閃點（°C）
Not applicable
Histone Deacetylase 3 Inhibition Overcomes
Azusa Tanimoto et al.
Clinical cancer research : an official journal of the American Association for Cancer Research, 23(12), 3139-3149 (2016-12-18)
Ying Huang et al.
Cellular & molecular biology letters, 23, 34-34 (2018-08-02)
Upregulation of histone acetylation plays a critical role in the dysregulation of transcription. It alters the structure of chromatin, which leads to the onset of cancer. Histone deacetylase inhibitors may therefore be a promising way to limit cancer progression. In
Gera Goverse et al.
Journal of immunology (Baltimore, Md. : 1950), 198(5), 2172-2181 (2017-01-20)
The gastrointestinal tract is continuously exposed to many environmental factors that influence intestinal epithelial cells and the underlying mucosal immune system. In this article, we demonstrate that dietary fiber and short chain fatty acids (SCFAs) induced the expression of the
Di Huang et al.
Nature immunology, 19(10), 1112-1125 (2018-09-19)
Activation-induced cell death (AICD) of T lymphocytes can be exploited by cancers to escape immunological destruction. We demonstrated that tumor-specific cytotoxic T lymphocytes (CTLs) and type 1 helper T (TH1) cells, rather than type 2 helper T cells and regulatory
Dominik Stammler et al.
Journal of immunology (Baltimore, Md. : 1950), 195(11), 5421-5431 (2015-11-01)
Histone deacetylase (HDAC) inhibitors (HDACi) are clinically approved anticancer drugs that have important immune-modulatory properties. We report the surprising finding that HDACi promote LPS-induced IL-1β processing and secretion in human and murine dendritic cells and murine macrophages. HDACi/LPS-induced IL-1β maturation
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