D1819
Anti-DYRK1A (C-terminal) antibody produced in rabbit
~1 mg/mL, affinity isolated antibody, buffered aqueous solution
别名:
Anti-Dual-specificity tyrosine-phosphorylation-regulated kinase 1A, Anti-MNB protein kinase, Anti-MNB/MNBH, Anti-Minibrain Drosophila homolog
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所有图片(1)
About This Item
分類程式碼代碼:
12352203
NACRES:
NA.41
生物源
rabbit
共軛
unconjugated
抗體表格
affinity isolated antibody
抗體產品種類
primary antibodies
無性繁殖
polyclonal
形狀
buffered aqueous solution
分子量
antigen ~86 kDa
物種活性
mouse, human, rat
濃度
~1 mg/mL
技術
western blot: 1-2 μg/mL using rat brain embryonic extract
western blot: 2-4 μg/mL using rat brain postnatal extract
UniProt登錄號
運輸包裝
dry ice
儲存溫度
−20°C
目標翻譯後修改
unmodified
基因資訊
human ... DYRK1A(1859)
mouse ... Dyrk1a(13548)
rat ... Dyrk1a(25255)
一般說明
Dual-specificity tyrosine-phosphorylated regulated kinase 1A (DYRK1A), also known as minibrain/Mnb is a member of a growing family of Ser/Thr protein kinases termed dual-specificity tyrosine phosphorylation-regulated kinases (DYRKs). DYRKs also possess autophosphorylation activity on tyrosine residues, located on the YXY motif of the activation loop of the catalytic domain.
The human and rodent DYRK1A are ubiquitously expressed in adult and fetal tissue with high expression in the brain and heart during development.
應用
Anti-DYRK1A (C-terminal) antibody produced in rabbit has been used in western blotting.
生化／生理作用
DYRK1A is encoded by a gene located within the Down syndrome (DS) critical region on human chromosome 21 and its expression is found to be elevated in individuals with DS. It might be one of the genes involved in some of the neurological abnormalities observed in DS. It phosphorylates several substrates including transcription factor FKHR, NFAT, STAT3, microtubule-associated protein Tau, glycogen synthase and c-AMP-response element-binding protein.
DYRK1A phosphorylates several substrates including transcription factor FKHR, NFAT, STAT3, microtubule-associated protein Tau, glycogen synthase and c-AMP-response element-binding protein.
外觀
Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide.
免責聲明
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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儲存類別代碼
12 - Non Combustible Liquids
水污染物質分類（WGK）
WGK 1
閃點（°F）
Not applicable
閃點（°C）
Not applicable
個人防護裝備
Eyeshields, Gloves
Emerging Roles of DYRK Kinases in Embryogenesis and Hedgehog Pathway Control
Singh R, et al.
Journal of developmental biology, 5(4) (2017)
DYRK1A-haploinsufficiency in mice causes autistic-like features and febrile seizures
Raveau M, et al.
Neurobiology of Disease, 110, 180-191 (2018)
Noriko Murakami et al.
The Journal of biological chemistry, 281(33), 23712-23724 (2006-05-31)
Minibrain kinase/dual-specificity tyrosine phosphorylation-regulated kinase (Mnb/Dyrk1A) is a proline-directed serine/threonine kinase encoded in the Down syndrome critical region of human chromosome 21. This kinase has been shown to phosphorylate dynamin 1 and synaptojanin 1. Here we report that amphiphysin I
Joseph R Arron et al.
Nature, 441(7093), 595-600 (2006-03-24)
Trisomy 21 results in Down's syndrome, but little is known about how a 1.5-fold increase in gene dosage produces the pleiotropic phenotypes of Down's syndrome. Here we report that two genes, DSCR1 and DYRK1A , lie within the critical region
W J Song et al.
Genomics, 38(3), 331-339 (1996-12-15)
The presence of an extra copy of human chromosome 21 (trisomy 21), especially region 21q22.2, causes many phenotypes in Down syndrome, including mental retardation. To study genes potentially responsible for some of these phenotypes, we cloned a human candidate gene
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