推荐产品
生物源
bovine
形狀
lyophilized powder
標籤範圍
~10 mol Digoxin per mol albumin
技術
inhibition assay: suitable
UniProt登錄號
儲存溫度
2-8°C
基因資訊
cow ... ALB(280717)
應用
Digoxin-BSA bovine is a cardioactive glycoside which can increase intracellular calcium concentration through Na+/K+-ATPase pump inhibition. Digoxin has been used in treatments of heart related disease and also studies of cancer treatments. It has shown the ability to inhibit prostate cancer cell growth, but has also shown a reduction in the efficiency of chemotherapy (reduced drug absorption) by increasing the amount of P-glycoprotein (Pgp).
生化／生理作用
Antigen-protein conjugate.
外觀
Lyophilized from 0.06 M Tris
儲存類別代碼
11 - Combustible Solids
水污染物質分類（WGK）
WGK 3
閃點（°F）
Not applicable
閃點（°C）
Not applicable
個人防護裝備
Eyeshields, Gloves, type N95 (US)
Y Ikeda et al.
Biological & pharmaceutical bulletin, 23(8), 906-910 (2000-08-30)
The preparation and antigenic properties of digoxin C-3' and C-3" hemisuccinate-bovine serum albumin (BSA) conjugates are described. The antisera were prepared by immunizing rabbits with each of the digoxin-BSA conjugates, and properties of the antisera were characterized by RIA with
Elizabeth A Platz et al.
Cancer discovery, 1(1), 68-77 (2011-12-06)
Identification of novel indications for commonly prescribed drugs could accelerate translation of therapies. We investigated whether any clinically-used drugs might have utility for treating prostate cancer by coupling an efficient, high-throughput laboratory-based screen and a large, prospective cohort study. In
S P O'Neill et al.
Journal of immunology (Baltimore, Md. : 1950), 116(2), 363-366 (1976-02-01)
Animals immunized with hapten-protein conjugates subsequently circulate high concentrations of hapten bound by antibody. The levels of hapten detected are capable of significantly reducing antibody titer in the sera immunized animals. In the case of steroid-protein conjugates, the main source
Chiara Riganti et al.
Toxicology and applied pharmacology, 240(3), 385-392 (2009-08-04)
Digoxin and ouabain are cardioactive glycosides, which inhibit the Na+/K+-ATPase pump and in this way they increase the intracellular concentration of cytosolic calcium ([Ca2+](i)). They are also strong inducers of the P-glycoprotein (Pgp), a transmembrane transporter which extrudes several drugs
Ioannis Prassas et al.
Molecular cancer therapeutics, 10(11), 2083-2093 (2011-08-24)
Cardiac glycosides (e.g., digoxin, digitoxin) constitute a diverse family of plant-derived sodium pump inhibitors that have been in clinical use for the treatment of heart-related diseases (congestive heart failure, atrial arrhythmia) for many years. Recently though, accumulating in vitro and
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