推荐产品
生物源
rabbit
品質等級
共軛
unconjugated
抗體表格
affinity isolated antibody
抗體產品種類
primary antibodies
無性繁殖
polyclonal
形狀
buffered aqueous solution
分子量
antigen 29 kDa
物種活性
rat, human, chicken
技術
immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:1,000 using formalin-fixed, paraffin-embedded rat cerebellum sections
microarray: suitable
western blot: 1:1,000 using recombinant human calretinin
UniProt登錄號
儲存溫度
−20°C
目標翻譯後修改
unmodified
基因資訊
human ... CALB2(794)
rat ... Calb2(117059)
一般說明
Anti-Calretinin is developed in rabbit using a synthetic peptide corresponding to the C-terminal region of rat calretinin (amino acids 194-209) conjugated to keyhole limpet hemocyanin (KLH) as immunogen. Calretinin is an intracellular Ca2+-binding protein, with broad tissue distribution and is a member of the calmodulin superfamily. It is expressed in certain populations of neurons in the central and peripheral nervous systems. It is abundant in the cerebellum (granule cells), olfactory bulb and auditory pathways.
免疫原
synthetic peptide corresponding to the C-terminal region of rat calretinin (amino acids 194-209) conjugated to KLH. This sequence is specific for calretinin and not found in other members of the EF-hand family such as calbindin-D-28K, calbindin-D-9K, myosin light chain, parvalbumin, S-100a, S-100b, S100A2 (S100L) and S100A6 (calcyclin). This sequence is identical in human and mouse calretinin and highly conserved in chicken calretinin.
應用
Anti-Calretinin antibody produced in rabbit has been used in immunohistochemistry and immunofluorescence.
Anti-Calretinin antibody produced in rabbit is suitable for the following applications:
- immunohistochemistry
- microarray
- western blotting at a dilution of 1:1,000 using recombinant human calretinin
生化／生理作用
The physiological function of calretinin is not known, but it seems to be related to Ca2+ buffering and diffusion. Calretinin-deficient mice show impaired long-term potentiation (LTP) in the dentate gyrus, impaired motor coordination and Purkinje cell excitability. A role for both calretinin and calbindin-D-28K in synaptic plasticity and in neuroprotection from excitotoxic insults has been postulated. By acting as a buffer or sensor of intracellular free Ca2+, calretinin promotes calcium homeostasis. Furthermore, several truncated forms of calretinin have been found in certain tumor cells, but are absent from normal cells, suggesting that calretinin may play a role in tumorigenesis.
外觀
Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 1% bovine serum albumin, and 15 mM sodium azide.
免責聲明
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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儲存類別代碼
10 - Combustible liquids
水污染物質分類（WGK）
WGK 3
閃點（°F）
Not applicable
閃點（°C）
Not applicable
其他客户在看
Calretinin: a gene for a novel calcium-binding protein expressed principally in neurons.
Rogers JH
The Journal of Cell Biology, 105(3), 1343-1353 (1987)
Immunocytochemical detection of calretinin in the claustrum and endopiriform nucleus of the chinchilla
Szalak R, et al.
Polish Journal of Veterinary Sciences, 18(4), 857-863 (2015)
Shuzi Owens et al.
American journal of physiology. Lung cellular and molecular physiology, 308(12), L1265-L1273 (2015-04-19)
Pleural organization follows acute injury and is characterized by pleural fibrosis, which may involve the visceral and parietal pleural surfaces. This process affects patients with complicated parapneumonic pleural effusions, empyema, and other pleural diseases prone to pleural fibrosis and loculation.
Sanda Alexandrescu et al.
International journal of clinical and experimental pathology, 6(12), 2955-2961 (2013-12-03)
The use of calretinin immunostain (IHC) in the evaluation of rectal suction biopsies for Hirschsprung disease (HD) has been reported by Kapur et al. and others. The first goal of this article is to report our institutional experience with the
Jadwiga Małdyk et al.
Polish journal of pathology : official journal of the Polish Society of Pathologists, 65(1), 34-39 (2014-08-15)
Hirschsprung disease (HD) is a congenital malformation defined as the absence of myenteric and submucosal ganglion cells (GCs) in the distal rectum and variable length of the contiguous bowel. The aim of this study was to assess the utility of
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