生物源
goat
品質等級
共軛
unconjugated
抗體表格
affinity isolated antibody
抗體產品種類
primary antibodies
無性繁殖
polyclonal
形狀
lyophilized powder
物種活性
mouse
技術
indirect ELISA: 0.1-0.4 μg/mL
western blot: 0.1-0.2 μg/mL
UniProt登錄號
儲存溫度
−20°C
目標翻譯後修改
unmodified
基因資訊
mouse ... Ctla4(12477)
一般說明
细胞毒性T淋巴细胞相关蛋白4(CTLA4)或分化簇152(CD152)是T细胞受体，属于免疫球蛋白超家族或CD28家族。它在辅助性T细胞(Th)表面表达。基因位于人染色体2q33上。由细胞质结构域、跨膜结构域和116氨基酸的V样结构域构成。通过选择性剪接形成膜形态和可溶形态，膜形态为同源二聚体形式，可溶形态为单体形式。
免疫原
纯化的重组小鼠细胞毒性T淋巴细胞相关分子4细胞外结构域（于小鼠NSO细胞中表达）。
生化／生理作用
CTLA4（细胞毒性T淋巴细胞相关蛋白4）负责抑制T细胞增殖，促进T细胞凋亡。该蛋白在抗原呈递后表达，因此与免疫和自身免疫病有关。也参与各种T细胞介导的自身免疫病发生。
外觀
从0.2 μm过滤的含有5％海藻糖的磷酸盐缓冲盐水（pH 7.4）中冻干。
免責聲明
除非我们的产品目录或产品附带的其他公司文档另有说明，否则我们的产品仅供研究使用，不得用于任何其他目的，包括但不限于未经授权的商业用途、体外诊断用途、离体或体内治疗用途或任何类型的消费或应用于人类或动物。
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儲存類別代碼
11 - Combustible Solids
水污染物質分類（WGK）
WGK 3
閃點（°F）
Not applicable
閃點（°C）
Not applicable
個人防護裝備
Eyeshields, Gloves, type N95 (US)
Aileen Weiwei Li et al.
Nature materials, 17(6), 528-534 (2018-03-07)
Existing strategies to enhance peptide immunogenicity for cancer vaccination generally require direct peptide alteration, which, beyond practical issues, may impact peptide presentation and result in vaccine variability. Here, we report a simple adsorption approach using polyethyleneimine (PEI) in a mesoporous
Daniele Saverino et al.
PloS one, 9(11), e112509-e112509 (2014-11-11)
Primary biliary cirrhosis (PBC) is a chronic autoimmune cholestatic liver disease frequently characterized by anti-mitochondrial autoantibodies (AMA). A minority of patients are AMA-negative. Cytotoxic-T-Lymphocyte-Antigen-4 (CTLA-4) is a surface molecule expressed on activated T-cells delivering a critical negative immunoregulatory signal. A
Sigrid Regauer et al.
Histology and histopathology, 29(8), 1017-1025 (2014-01-10)
Introduction. Lichen planus (LP) is a chronic cytokine-mediated disease of possible auto-immune etiology. 25% of men have anogenital manifestations. Erosive penile LP causes a scarring phimosis of the foreskin in uncircumcised men. Mast cells as potent immune modulators have been
Jonas Pick et al.
European journal of immunology, 44(7), 2139-2152 (2014-04-12)
Although CD8(+) T cells that produce IL-17 (Tc17 cells) have been linked to host defense, Tc17 cells show reduced cytotoxic activity, which is the characteristic function of CD8(+) T cells. Here, we show that CTLA-4 enhances the frequency of IL-17 in
Chindu Govindaraj et al.
American journal of hematology, 89(8), 795-802 (2014-04-24)
A major limitation to improved outcomes in acute myelogenous leukemia (AML) is relapse resulting from leukemic cells that persist at clinical remission. Regulatory T cells (Tregs), which are increased in AML patients, can contribute to immune evasion by residual leukemic
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