推荐产品
重組細胞
expressed in E. coli
品質等級
化驗
>90% (SDS-PAGE)
形狀
lyophilized powder
比活性
8,000 units/mg protein (Bradford)
分子量
~30 kDa
溶解度
PBS: soluble
UniProt登錄號
運輸包裝
dry ice
儲存溫度
−70°C
基因資訊
human ... CASP10(843)
生化／生理作用
Caspase 10 has two death effector domains (DEDs) that bind to the DED in the adapter molecule FADD and recruits both TNFR1 and CD95 to form complexes with these receptors. Caspase 10 cleaves and activates caspases 3, 4, 6, 7, 8 and 9 which causes the proteolytic cleavage of many key proteins such as PARP. Based on gene expression studies, caspase 10 may be crucial in embryonic development. In view of its structural homology to caspase 8, the initiator caspase in death receptor-mediated apoptosis, caspase 10 may function in a similar and redundant manner.
單位定義
One unit will hydrolyze 1 nmol of the caspase substrate IETD-pNA to IETD and p-nitroaniline per hour at pH 7.2 at 37 °C.
外觀
Lyophilized powder containing 0.052% ammonium sulfate, 0.158% Tris−HCl, and 0.76% sodium chloride.
儲存類別代碼
10 - Combustible liquids
水污染物質分類（WGK）
nwg
閃點（°F）
Not applicable
閃點（°C）
Not applicable
Caspases: the executioners of apoptosis.
Cohen, G.M.
Biochemistry, 326 (part 1), 1-1 (1997)
Marcin Poreba et al.
Nature protocols, 12(10), 2189-2214 (2017-09-22)
Many biologically and chemically based approaches have been developed to design highly active and selective protease substrates and probes. It is, however, difficult to find substrate sequences that are truly selective for any given protease, as different proteases can demonstrate
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