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應用
来自 Sigma 的酶已在各种研究中用于胆汁样品的分析。
生化／生理作用
该酶是一种 N-末端亲核 (Ntn) 水解酶，催化酰胺键水解，从类固醇核心释放甘氨酸/牛磺酸部分，最终生成非结合胆汁酸。已证明可氧化巯基的药物（例如，对汞苯甲酸盐、碘乙酰胺、Hg 2 + 、Cu 2 + 和 Cd 2 + ）可强烈抑制 产气荚膜梭菌的胆盐水解酶 (BSH) 活性 。
單位定義
一个单元将在37°C、pH 5.6 条件下5 min 内将 1.0μmol 甘胆酸水解为甘氨酸和胆酸。
外觀
部分纯化的冻干粉末，含有缓冲盐和稳定剂
訊號詞
Danger
危險聲明
危險分類
Resp. Sens. 1
儲存類別代碼
11 - Combustible Solids
水污染物質分類（WGK）
WGK 1
閃點（°F）
Not applicable
閃點（°C）
Not applicable
個人防護裝備
Eyeshields, Gloves, type N95 (US)
Bile salt hydrolase activity in probiotics.
Máire Begley et al.
Applied and environmental microbiology, 72(3), 1729-1738 (2006-03-07)
Effects of Quercetin and Rutin on Serum and Hepatic Lipid Concentrations, Fecal Steroid Excretion and Serum Antioxidant Properties
Nakamura Y, et al.
Journal of Health Science, 46(4), 229-240 (2000)
Maksim Rossocha et al.
Biochemistry, 44(15), 5739-5748 (2005-04-13)
Bacterial bile salt hydrolases catalyze the degradation of conjugated bile acids in the mammalian gut. The crystal structures of conjugated bile acid hydrolase (CBAH) from Clostridium perfringens as apoenzyme and in complex with taurodeoxycholate that was hydrolyzed to the reaction
Anil K Patel et al.
Applied biochemistry and biotechnology, 162(1), 166-180 (2009-08-12)
Probiotic has modernized the current dietetic sense with novel therapeutic and nutritional benefits to the consumers. The presence of bile salt hydrolase (BSH) in probiotics renders them more tolerant to bile salts, which also helps to reduce the blood cholesterol
F Kannenberg et al.
The Journal of biological chemistry, 274(50), 35455-35460 (1999-12-10)
Peroxisomal beta-oxidation plays an important role in the metabolism of a wide range of substrates, including various fatty acids and the steroid side chain in bile acid synthesis. Two distinct thiolases have been implicated to function in peroxisomal beta-oxidation: the
实验方案
To standardize a procedure for the determination of the enzymatic assay of choloylglycine hydrolase.
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