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品質等級
化驗
≥98% (HPLC)
形狀
powder
溶解度
DMSO: ≥8 mg/mL
起源
Novartis
儲存溫度
room temp
SMILES 字串
CN1CCC(\CC1)=C2\c3ccccc3CCc4sccc24
InChI
1S/C19H21NS/c1-20-11-8-15(9-12-20)19-16-5-3-2-4-14(16)6-7-18-17(19)10-13-21-18/h2-5,10,13H,6-9,11-12H2,1H3
InChI 密鑰
FIADGNVRKBPQEU-UHFFFAOYSA-N
生化／生理作用
Pizotifen is a serotonin antagonist acting mainly at the 5-HT1, 5-HT2A and 5HT2C receptors with some antihistamine activity. It is used for the prevention of vascular headache including migraine and cluster headache.
特點和優勢
This compound was developed by Novartis. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.
訊號詞
Warning
危險聲明
危險分類
Acute Tox. 4 Oral - Repr. 2
儲存類別代碼
11 - Combustible Solids
水污染物質分類（WGK）
WGK 3
閃點（°F）
Not applicable
閃點（°C）
Not applicable
Paul Silcocks et al.
Trials, 11, 71-71 (2010-06-18)
A recent Cochrane Review demonstrated the remarkable lack of reliable clinical trials of migraine treatments for children, especially for the two most prescribed preventative treatments in the UK, Propranolol and Pizotifen.Migraine trials in both children and adults have high placebo
M H Guillet et al.
Annales de dermatologie et de venereologie, 122(11-12), 777-779 (1995-01-01)
Primary erythermalgia is a rare acrosyndrome due to paroxystic arteriolar dilatation of extremities that become red and congested with warmth and burning sensation or pain. We report herein the observation of a primary erythermalgia affecting 3 degrees in the same
Arthur T Strachan et al.
Medicine and science in sports and exercise, 37(3), 389-394 (2005-03-03)
The effect of serotonin (5-HT)2C receptor blockade on the thermal response and exercise performance during exercise in a warm environment was examined. Seven endurance-trained, but not heat-acclimatized, individuals (six males and one female) performed two 40-km time trials on a
G L Briars et al.
Archives of disease in childhood, 93(7), 590-593 (2008-04-03)
To describe the characteristics of weight gain occurring in children treated for migranous conditions with pizotifen Retrospective case note review West Suffolk Hospital between 1999 and 2003 PATIENTS: 405 clinic attendances of 121 children receiving pizotifen treatment Rates of change
Tomasz Huć et al.
Pharmacological research, 130, 172-179 (2017-12-31)
Arterial blood pressure (BP) is regulated by a complex network of peripheral and central (brain) mechanisms. Research suggests that gut bacteria-derived compounds may affect the circulatory system. We evaluated hemodynamic effects of indole, a gut bacteria-derived product of tryptophan, and
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