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化驗
≥98% (GC)
形狀
powder
顏色
white
mp
73-74 °C (lit.)
溶解度
DMSO: soluble
儲存溫度
−20°C
SMILES 字串
CC(C)(C)[N+](\[O-])=C\c1ccccc1
InChI
1S/C11H15NO/c1-11(2,3)12(13)9-10-7-5-4-6-8-10/h4-9H,1-3H3/b12-9-
InChI 密鑰
IYSYLWYGCWTJSG-XFXZXTDPSA-N
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應用
N-叔丁基-α-苯基硝酮已用于：
- 用作Dneasy Blood&血液组织缓冲液组分，以保留从人类非致瘤性上皮性乳腺癌（MCF10A）细胞中提取的氧化态DNA
- 用作微胶质（MG）细胞系活性氧(ROS)自由基清除试剂
- 衰减不稳定口腔鳞状细胞癌（GU-OSCC）中的成纤维细胞衰老
生化／生理作用
N-叔丁基-α-苯基硝酮（PBN）是一种常用的自由基自旋捕获剂。已有研究表明，PBN具有自由基清除活性以及抑制环氧合酶-2活性的能力，因此，它可以减少兔皮质中栓子诱导的脑微梗死的数量并预防肿瘤形成。据报道，PBN可抑制诱导型一氧化氮合酶（iNOS），从而防止一氧化氮（NO）过量产生。 PBN以100 mg/kg腹腔注射，可减少氟替尔诱导大鼠癫痫持续状态中的黑质网状部坏死。它可以预防癫痫动物模型中某些类型的创伤后致癫痫事件。已有研究发现，大鼠的PBN致死剂量约为100 mg/100 g体重（0.564 mmol/100Å g）。
儲存類別代碼
11 - Combustible Solids
水污染物質分類（WGK）
WGK 3
閃點（°F）
Not applicable
閃點（°C）
Not applicable
個人防護裝備
Eyeshields, Gloves, type N95 (US)
microRNA-34a-mediated down-regulation of the microglial-enriched triggering receptor and phagocytosis-sensor TREM2 in age-related macular degeneration
Bhattacharjee S, et al.
Testing, 11(3), e0150211-e0150211 (2016)
Genome-wide mapping of 8-oxo-7, 8-dihydro-2?-deoxyguanosine reveals accumulation of oxidatively-generated damage at DNA replication origins within transcribed long genes of mammalian cells
Amente S, et al.
Nucleic Acids Research, 47(1), 221-236 (2018)
Progression of genotype-specific oral cancer leads to senescence of cancer-associated fibroblasts and is mediated by oxidative stress and TGF-beta
Hassona Y, et al.
Carcinogenesis, 34(6), 1286-1295 (2013)
Mark C Fogarty et al.
Environmental and molecular mutagenesis, 52(1), 35-42 (2010-09-15)
Exercise-induced deoxyribonucleic acid (DNA) damage is often associated with an increase in free radicals; however, there is a lack of evidence examining the two in parallel. This study tested the hypothesis that high-intensity exercise has the ability to produce free
Zhen Wang et al.
Toxicology and applied pharmacology, 259(2), 236-247 (2012-01-19)
The placenta is essential for sustaining the growth of the fetus. An increased endoplasmic reticulum (ER) stress has been associated with the impaired placental and fetal development. Cadmium (Cd) is a potent teratogen that caused fetal malformation and growth restriction.
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