B6060

BVT.948

≥98% (HPLC), solid

• 别名: 4-Hydroxy-3,3-dimethyl-2H-benzo[g]indole-2,5(3H)-dione
• 经验公式（希尔记法）: C₁₄H₁₁NO₃
• CAS号: 39674-97-0
• 分子量: 241.24
• MDL號碼: MFCD00616487
• 分類程式碼代碼: 12352200
• PubChem物質ID: 24724422
• NACRES: NA.77

属性

• 化驗: ≥98% (HPLC)
• 形狀: solid
• 儲存條件: desiccated; protect from light; under inert gas
• 顏色: red
• 溶解度: DMSO: 18 mg/mL; H₂O: insoluble
• 儲存溫度: −20°C
• SMILES 字串: CC1(C)C(=O)N=C2c3ccccc3C(=O)C(O)=C12
• InChI: 1S/C14H11NO3/c1-14(2)9-10(15-13(14)18)7-5-3-4-6-8(7)11(16)12(9)17/h3-6,17H,1-2H3
• InChI 密鑰: BAQXWJQSUXZVIP-UHFFFAOYSA-N

说明

生化／生理作用

BVT.948 is a non-competitive inhibitor of protein tyrosine phosphatase (PTP). Enhances insulin signaling in cells and inhibits several cytochrome P450 isoforms in vitro.

特點和優勢

BVT.948 is a non-competitive inhibitor of protein tyrosine phosphatase (PTP). Enhances insulin signaling in cells and inhibits several cytochrome P450 isoforms in vitro. Works through a different mechanism then the other PTP inhibitors. BVT.948 was able to enhance insulin signaling in cells, although it did not increase tyrosine phosphorylation globally. Furthermore, the compound was active in vivo, enhancing insulin tolerance tests in ob/ob mice, therefore apparently enhancing insulin sensitivity. BVT.948 was able to inhibit several other PTPs tested and also was efficient at inhibiting several cytochrome P450 isoforms in vitro.

安全信息

• 象形圖: GHS07
• 訊號詞: Warning
• 危險聲明: H317
• 防範說明: P261 - P272 - P280 - P302 + P352 - P333 + P313 - P362 + P364
• 危險分類: Skin Sens. 1
• 儲存類別代碼: 11 - Combustible Solids
• 水污染物質分類（WGK）: WGK 3
• 閃點（°F）: Not applicable
• 閃點（°C）: Not applicable
• 個人防護裝備: dust mask type N95 (US), Eyeshields, Faceshields, Gloves