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Key Documents

B354-05

Sigma-Aldrich

Bovine Aortic Smooth Muscle Cells: BAOSMC (Cryovial)

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About This Item

分類程式碼代碼:
41106514
NACRES:
NA.81

生物源

bovine artery (USDA-inspected cattle)

包裝

pkg of 500,000 cells

製造商/商標名

Cell Applications, Inc

增長模式

Adherent

染色體組型

2n = 60

形態學

smooth muscle

技術

cell culture | mammalian: suitable

相關疾病

cardiovascular diseases

運輸包裝

dry ice

儲存溫度

−196°C

一般說明

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Bovine large artery smooth muscle cells (BAOSMC) provide an excellent model system to study all aspects of cardiovascular function and disease, especially those related to mechanisms of hyperplasia and hypertrophy of intimal smooth muscle cells leading to vascular occlusion in atherosclerosis and stent restenosis.

BAOSMC have been utilized in a number of research studies, for example, to:
  • Elucidate RhoA-dependent serum response signaling pathways (Gudi, 2002); the role of FAK in thrombospondin-1 induced migration of vascular smooth muscle cells (Wang, 2008)
  • Demonstrate the relationship between the disturbed flow and proliferation of smooth muscle cells, leading to intima hyperplasia (Fan, 2010); and study interactions between lipoproteins and extracellular matrix, as well as mechanisms of lipoprotein aggregation contributing to atherosclerosis (Sakr, 2001)
  • Construct an expression cassette to maximize targeted transgene expression (Dronadula, 2010)
  • Test new technologies, such as on-chip contact imaging technique (Liu, 2004; Ji, 2005, 2007; Prakash, 2007), handheld fluorometers (Nelson, 2009) and a “nose on a chip” olfactory sensor (Patel, 2011)
  • Study the behavior of smooth muscle cells in 3d environment (Du, 2008) and smooth muscle/endothelial co-cultures (Niwa, 2007; Fan, 2008; Mathura, 2013); describe an origami-like method of generating three-dimensional (3D) cell-laden microstructures (Kuribayashi-Shigetomi, 2012); and design materials for tissue engineering and cardiovascular implants (Mathews, 2006, 2008)

    Characterization: positive for smooth muscle cell specific alpha-actin expression.

細胞系來源

Artery

應用

aortic wall contraction, role of smc under normal conditions, blood pressure, distribution of oxygenated blood through systemic circulation

成分

Bovine Smooth Muscle Cell Basal Medium containing 10% FBS & 10% DMSO

準備報告

  • 2nd passage, >500,000 cells in Bovine Smooth Muscle Cell Basal Medium containing 10% FBS & 10% DMSO
  • Can be cultured at least 16 doublings

例行更新培養

Please refer to the BAOSMC Culture Protocol.

儲存類別代碼

11 - Combustible Solids

水污染物質分類(WGK)

WGK 3

閃點(°F)

Not applicable

閃點(°C)

Not applicable


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实验方案

Store the cryovials in a liquid nitrogen storage tank immediately upon arrival.

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