B0939
活性BAFF 人
Animal-component free, recombinant, expressed in Nicotiana, >97% (SDS-PAGE)
别名:
B lymphocyte stimulator, B-cell-activating factor BAFF, BLyS, Dendritic cell-derived TNF-like molecule, TALL-1, TNF- and APOL-related leukocyte expressed ligand 1
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所有图片(1)
About This Item
分類程式碼代碼:
12352202
NACRES:
NA.32
推荐产品
生物源
human
品質等級
重組細胞
expressed in Nicotiana
化驗
>97% (SDS-PAGE)
形狀
lyophilized
效力
≤50 ng/mL ED50
分子量
18-20 kDa (a glycosilated polypeptide chain containing 151 amino acids)
包裝
pkg of 10 μg
儲存條件
avoid repeated freeze/thaw cycles
雜質
Endotoxin, tested (LAL test, < 0.04 EU/ ug protein)
UniProt登錄號
儲存溫度
−20°C
基因資訊
human ... TNFSF13B(10673)
相关类别
一般說明
BAFF (B lymphocyte activating factor) is a member of the tumor necrosis factor (TNF) ligand family which is expressed in T Cells, macrophages, monocytes and dendritic cells. It is also known as BLyS, THANK, TALL, zTNF4 and TNFS20. BAFF enhances B cell survival in vitro and has emerged as a key regulator of peripheric B cell and it is vital homeostatic cytokine for B cells that helps regulate both innate and adaptive immune responses. BAFF binds to three TNF receptors: B-cell maturation antigen (BCMA/TNFRSF17), transmembrane activator and calcium modulator and cyclophilin ligand interactor(TACI/TNFRSF13B) and BAFF receptor (BAFF R/BR3/TNFRSF 13C).The human BAFF gene code for a 285 amino acids type II transmembrane protein. Recombinant human soluble BAFF is a 151 amino acids containing the TNF-like portion of the extracellular domain of BAFF.
外觀
Lyophilized from a 20 mM PBS buffer at pH 7 and 0.2 M NaCl.
重構
Lyophilized protein should be reconstituted in water to a concentration of 25 - 50 ng /μl. Due to the protein nature, dimmers and multimers may be observed.
分析報告
The activity is determined by dose-dependeant stimulation of proliferation B cell from Human PBMC. Cell proliferation was measured by MTT method.
*activity results may vary with PBMC donors.
ED50 ≤ 50 ng/mL
*activity results may vary with PBMC donors.
ED50 ≤ 50 ng/mL
其他說明
Extinction Coefficient: E0.1% = 0.791 (A280 nm)
p.I: 6.03
p.I: 6.03
儲存類別代碼
10 - Combustible liquids
水污染物質分類（WGK）
WGK 1
閃點（°F）
Not applicable
閃點（°C）
Not applicable
Rita R Barbosa et al.
Journal of clinical immunology, 34(5), 573-583 (2014-05-09)
B-cell survival and differentiation critically depend on the interaction of BAFF-R and TACI with their ligands, BAFF and APRIL. Mature B-cell defects lead to Common Variable Immunodeficiency (CVID), which is associated with elevated serum levels of BAFF and APRIL. Nevertheless
Xiao-Juan Zhu et al.
British journal of haematology, 166(5), 783-791 (2014-06-04)
To investigate the expression of tumour necrosis factor superfamily 13B (TNFSF13B) receptors in immune thrombocytopenia (ITP) and their correlation with disease activity, we investigated the protein and mRNA levels of TNFSF13B, tumour necrosis factor receptor superfamily 13C (TNFRSF13C), TNFRSF13B and
Nuoyan Zheng et al.
BMC nephrology, 16, 72-72 (2015-05-16)
B cell activating factor belonging to the TNF family (BAFF) is vital for B cell survival, proliferation and activation. Evidence indicates that BAFF is systemically or locally increased in glomerulonephritis (e.g. lupus nephritis, IgA nephropathy). However, the effect of BAFF
J Wild et al.
Leukemia, 29(8), 1676-1683 (2015-02-25)
Natural killer (NK) cells are cytotoxic lymphocytes that substantially contribute to the therapeutic benefit of antitumor antibodies like Rituximab, a crucial component in the treatment of B-cell malignancies. In chronic lymphocytic leukemia (CLL), the ability of NK cells to lyse
Yoshiko Matsuda et al.
Cellular immunology, 295(2), 127-136 (2015-04-17)
Long-lived plasma cells (PCs) contribute to humoral immunity through an undefined mechanism. Memory B cells, but not human naïve B cells, can be induced to differentiate into long-lived PCs in vitro. Because evidence links a proliferation-inducing ligand (APRIL), a tumor
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