推荐产品
生物源
mouse
品質等級
共軛
unconjugated
抗體表格
purified immunoglobulin
抗體產品種類
primary antibodies
無性繁殖
203-217/6, monoclonal
形狀
buffered aqueous solution
分子量
antigen 47-51 kDa
物種活性
mouse, canine, rat, chicken, bovine, human, rabbit
技術
immunocytochemistry: suitable using methanol or 1% paraformaldehyde/0.1% glutaraldehyde
immunohistochemistry (frozen sections): suitable
microarray: suitable
western blot: 0.5-1 μg/mL using whole cell extract of culture mouse connective tissue (A9) cells.
同型
IgG1
UniProt登錄號
運輸包裝
dry ice
儲存溫度
−20°C
目標翻譯後修改
unmodified
基因資訊
human ... ANXA7(310)
mouse ... Anxa7(11750)
rat ... Anxa7(155423)
一般說明
Annexin VII (synexin) is a membrane binding protein that localizes in the nucleus and cytosol. In humans and mice, Annexin VII is encoded by a single gene that has alternatively spliced cassette exons. As a result, two isoforms of molecular mass of 47kDa and 51kDa are expressed. These isoforms differ in their N-terminal region and also have distinct tissue-specific expression patterns.
Anti-Annexin VII antibody, Mouse monoclonal (mouse IgG1 isotype) is derived from the 203-217/6 hybridoma produced by the fusion of mouse myeloma cells and splenocytes from BALB/c mice immunized with a recombinant mouse Annexin VII. The human annexin VII (ANXA7) is located on chromosome 10q21.
特異性
Mouse monoclonal anti-annexin VII antibody reacts with human, bovine, rabbit, dog, rat, mouse, and chicken Annexin VII.
免疫原
recombinant mouse annexin VII.
應用
Anti-Annexin VII antibody, Mouse monoclonal has been used in:
- western blotting
- immunocytochemistry
- immunohistochemistry
生化／生理作用
Antibodies reacting specifically with Annexin VII serve as an essential tool for the detection of this molecule in various cells. The human annexin VII (ANXA7) possesses a tumor suppressor role in prostate cancer. Hence it can be used an important biomarker along with syndecan-1 to predict the survival rates in prostate cancer patients.
外觀
Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 1% bovine serum albumin and 15 mM sodium azide.
免責聲明
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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儲存類別代碼
12 - Non Combustible Liquids
水污染物質分類（WGK）
WGK 2
閃點（°F）
Not applicable
閃點（°C）
Not applicable
Yanling Jin et al.
BMC cancer, 13, 522-522 (2013-11-06)
Hepatocellular carcinoma (HCC) is one of the leading causes of cancer death in China. This study investigated the effects of Annexin A7 (ANXA7) on the inhibition of HCC lymph node metastasis in a mouse model. The stable knockup and knockdown
Yanling Jin et al.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 67(4), 337-345 (2013-04-16)
Cancer stem cells (CSCs), stem-like cells, or tumor-initiating cells (TICs) may initiate tumorigenesis and metastasis, but neither the basic cell biology of CSCs nor the mechanisms of CSC-mediated tumor growth and lymphoid node metastasis are understood. Evidence suggests that CSC
Annexin A7 suppresses lymph node metastasis of hepatocarcinoma cells in a mouse model
Jin Y, et al.
BMC Cancer, 13(1), 522-522 (2013)
Tissue microarray analysis delineate potential prognostic role of Annexin A7 in prostate cancer progression
Leighton X, et al.
Testing, 13(10), e0205837-e0205837 (2018)
S Selbert et al.
Experimental cell research, 222(1), 199-208 (1996-01-10)
Annexin VII (synexin) is a member of the annexin family of proteins, which are characterized by Ca(2+)-dependent binding to phospholipids. In normal skeletal muscle annexin VII is located preferentially at the plasma membrane and the t-tubule system [Selbert et al.
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