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生物源
bovine liver
品質等級
形狀
powder
比活性
≥100 units/mg protein
成份
Protein, ≥70% biuret
UniProt登錄號
運輸包裝
dry ice
儲存溫度
−20°C
基因資訊
cow ... ARG2(518752)
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一般說明
L-精氨酸酶也称为L-精氨酸氨基水解酶。它具有两种形式,如精氨酸酶-1和精氨酸酶-2。精氨酸酶1存在于肝细胞中,精氨酸酶2通常存在于肝外组织,如肾脏、大脑、骨骼肌、小肠和哺乳期乳腺。精氨酸酶-2位于人染色体14q24.1−24.3上。
生化/生理作用
L-精氨酸酶将L-精氨酸水解为L-鸟氨酸和尿素,这是排尿素物种的肝脏中尿素循环的最后一步。精氨酸酶在哺乳动物免疫系统中发挥主要作用,并且参与炎症的多个方面。
L-精氨酸酶是精氨酸的主要降解酶;它能够将精氨酸转化为鸟氨酸;缺乏该酶与痉挛和运动功能障碍有关。
單位定義
一个酶活性单位是指在pH 9.5、37 °C下,每分钟水解1.0μmol L-精氨酸所需的酶量。
訊號詞
Danger
危險聲明
危險分類
Resp. Sens. 1
儲存類別代碼
11 - Combustible Solids
水污染物質分類(WGK)
WGK 1
閃點(°F)
Not applicable
閃點(°C)
Not applicable
個人防護裝備
Eyeshields, Gloves, type N95 (US)
其他客户在看
L-Arginase: a Medically Important Enzyme
Research Journal of Pharmacy and Technology, 6(12), 1430-1430 (2013)
Arginase: an emerging key player in the mammalian immune system
British Journal of Pharmacology, 158(3), 638-651 (2009)
Biochemistry, 52(3), 508-519 (2012-12-29)
Urea producing bimetallic arginases are essential for the synthesis of polyamine, DNA, and RNA. Despite conservation of the signature motifs in all arginases, a nonconserved ¹⁵³ESEEKAWQKLCSL¹⁶⁵ motif is found in the Helicobacter pylori enzyme, whose role is yet unknown. Using
PloS one, 8(1), e54464-e54464 (2013-02-01)
Rapidly growing tumor cells require a nutrient-rich environment in order to thrive, therefore, restricting access to certain key amino acids, such as arginine, often results in the death of malignant cells, which frequently display defective cell cycle check-point control. Healthy
Methods in molecular biology (Clifton, N.J.), 946, 225-239 (2012-11-28)
Macrophages play a key role in the innate immune response and help to direct the acquired immune response. Early in the innate immune response, they produce reactive oxygen species and pro-inflammatory cytokines and chemokines to drive inflammation and are referred
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