A2559

N-Acetyl-Asp-Glu-Val-Asp p-nitroanilide

≥97% (HPLC), powder

• 别名: Ac-DEVD-pNA
• 经验公式（希尔记法）: C₂₆H₃₄N₆O₁₃
• CAS号: 189950-66-1
• 分子量: 638.58
• MDL號碼: MFCD00792707
• 分類程式碼代碼: 12352209
• PubChem物質ID: 24890668
• NACRES: NA.32

属性

• 化驗: ≥97% (HPLC)
• 形狀: powder
• 顏色: white
• 儲存溫度: −20°C
• SMILES 字串: CC(C)[C@H](NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CC(O)=O)NC(C)=O)C(=O)N[C@@H](CC(O)=O)C(=O)Nc1ccc(cc1)[N+]([O-])=O
• InChI: 1S/C26H34N6O13/c1-12(2)22(26(43)30-18(11-21(38)39)24(41)28-14-4-6-15(7-5-14)32(44)45)31-23(40)16(8-9-19(34)35)29-25(42)17(10-20(36)37)27-13(3)33/h4-7,12,16-18,22H,8-11H2,1-3H3,(H,27,33)(H,28,41)(H,29,42)(H,30,43)(H,31,40)(H,34,35)(H,36,37)(H,38,39)/t16-,17-,18-,22-/m0/s1
• InChI 密鑰: GGXRLUDNGFFUKI-ORGXJRBJSA-N
• 基因資訊: human ... CASP3(836)

说明

Amino Acid Sequence

NAc-Asp-Glu-Val-Asp-pNA

應用

N-Acetyl-Asp-Glu-Val-Asp p-nitroanilide has been used as a chromogenic substrates for determining caspase-3 and caspase-8 activities in liver tissue homogenates and caspase 3 activity in aortic vascular smooth muscle cells and neuroblastoma cell lines.

生化／生理作用

Colorimetric substrate for caspase 3, a protease that is rapidly activated when cells are exposed to apoptotic conditions and that cleaves poly(ADP-ribose) polymerase.

安全信息

• 儲存類別代碼: 11 - Combustible Solids
• 水污染物質分類（WGK）: WGK 3
• 閃點（°F）: Not applicable
• 閃點（°C）: Not applicable
• 個人防護裝備: Eyeshields, Gloves, type N95 (US)