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A2024

Sigma-Aldrich

阿普拉霉素 硫酸盐

别名:

Nebramycin II

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About This Item

经验公式（希尔记法）:
C21H41N5O11 · xH2SO4
CAS号:
65710-07-8
分子量:
539.58 (free base basis)
EC號碼:
265-890-7
MDL號碼:
MFCD06200257
分類程式碼代碼:
51281633
PubChem物質ID:
329770728
NACRES:
NA.85

生物源

Streptomyces tenebrarius

品質等級

200

形狀

powder

顏色

white to brown

抗生素活性譜

Gram-negative bacteria

作用方式

protein synthesis | interferes

儲存溫度

2-8°C

SMILES 字串

OS(O)(=O)=O.CN[C@H]1[C@@H](O)[C@H]2O[C@H](O[C@@H]3[C@@H](N)C[C@@H](N)[C@H](O)[C@H]3O)[C@H](N)C[C@@H]2O[C@@H]1O[C@H]4O[C@H](CO)[C@@H](N)[C@H](O)[C@H]4O

InChI

1S/C21H41N5O11.H2O4S/c1-26-11-14(30)18-8(33-20(11)37-21-16(32)13(29)10(25)9(4-27)34-21)3-7(24)19(36-18)35-17-6(23)2-5(22)12(28)15(17)31;1-5(2,3)4/h5-21,26-32H,2-4,22-25H2,1H3;(H2,1,2,3,4)/t5-,6+,7-,8+,9-,10-,11+,12+,13+,14-,15-,16-,17-,18+,19+,20-,21-;/m1./s1

InChI 密鑰

WGLYHYWDYPSNPF-RQFIXDHTSA-N

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一般說明

化学结构：氨基糖苷类

應用

阿霉素用于研究细菌和原核生物的抗生素耐药性以及蛋白质合成易位步骤抑制。

生化／生理作用

阿霉素通过阻断易位抑制蛋白质合成。它还能结合真核解码位点。在低浓度下，它会抑制延伸和诱导mRNA在蛋白质合成的误读。

包裝

1G，5G

其他說明

保存于密闭容器内，置于干燥通风处。请存放在干燥处。储存等级（TRGS 510）：不可燃急性毒性3类/有毒有害物质或引起慢性影响的有害物质。

象形圖

Health hazard
GHS08

訊號詞

Danger

危險聲明

H360FD

危險分類

Repr. 1B

儲存類別代碼

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

水污染物質分類（WGK）

WGK 3

閃點（°F）

Not applicable

閃點（°C）

Not applicable

個人防護裝備

Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges, type P3 (EN 143) respirator cartridges

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C M Yates et al.
The Journal of antimicrobial chemotherapy, 54(2), 534-537 (2004-07-03)
The aminoglycoside apramycin has been used extensively in animal husbandry in the UK since 1978. This study aimed to determine both whether calves that had never been treated with aminoglycoside antibiotics harboured apramycin-resistant (apr(R)) commensal Escherichia coli, and the mode
Min-Jung Choi et al.
Foodborne pathogens and disease, 8(1), 119-123 (2011-01-11)
A total of 1921 Escherichia coli isolated from healthy animals (501 from cattle, 832 from pigs, and 588 from chickens) and 237 isolates from diseased pigs were tested to determine the prevalence of apramycin and gentamicin resistance in Korea during
Kristina Kadlec et al.
The Journal of antimicrobial chemotherapy, 67(10), 2342-2345 (2012-06-22)
The aims of this study were to identify small staphylococcal plasmids that carry either the trimethoprim resistance gene dfrK or the apramycin resistance gene apmA and analyse them for their structure and organization with regard to their potential role as
T-W Hahn et al.
Journal of animal science, 84(6), 1422-1428 (2006-05-16)
Two experiments were conducted to evaluate the efficacy of beta-glucan on growth performance, nutrient digestibility, and immunity in weanling pigs. In Exp. 1, 210 weanling pigs (6.38 +/- 0.92 kg of BW) were fed dietary beta-glucan (0, 0.01, 0.02, 0.03
Mingxuan Xu et al.
Science in China. Series C, Life sciences, 49(4), 362-369 (2006-09-23)
Apramycin is unique in the aminoglycoside family due to its octodiose moiety. However, either the biosynthesis process or the precursors involved are largely unknown. Addition of glycine, as well as serine or threonine, to the Streptomyces tenebrabrius UD2 fermentation medium
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