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生物源
goat
品質等級
重組細胞
expressed in goat
共軛
unconjugated
抗體表格
affinity isolated antibody
抗體產品種類
primary antibodies
無性繁殖
polyclonal
形狀
lyophilized powder
物種活性
human
技術
ELISA: suitable
immunohistochemistry (formalin-fixed, paraffin-embedded sections): 5-15 μg/mL
neutralization: suitable
western blot: 0.1 μg/mL
UniProt登錄號
應用
research pathology
儲存溫度
−20°C
目標翻譯後修改
unmodified
基因資訊
human ... INHBA(3624)
一般說明
Activin A protein belongs to the transforming growth factor-β (TGF-β) superfamily. This protein is a homodimer of two βA subunits. The INHBA gene is located on the human chromosome at 7p14.1.
免疫原
recombinant human activin A expressed in CHO cells.
應用
Anti-Activin A antibody can be used for immunohistochemistry (5-15 μg/mL), western blot (0.1 μg/mL) and neutralization assays.
Anti-Activin A antibody produced in goat has been used in immunohistochemical staining.
生化／生理作用
Activin A protein is involved in regulating developmental genes such as cell cycle regulators like p21, p15, paired box protein (Pax-6) and hormones like follicle-stimulating hormone (FSH). This protein also regulates its antagonist like follistatin and mothers against decapentaplegic homolog 7 (SMAD7). Activin A protein binds to the type 1 receptor activin receptor type 1B (ActR1B) and type 2 receptor activin receptor 2A and 2B (ActRIIA and ActRIIB). Activin A gene is highly expressed in esophageal carcinoma, lung adenocarcinoma, and malignant pleural mesothelioma (MPM). This gene expression is decreased during breast cancer, neuroblastoma, and hepatocellular carcinoma (HCC). Activins bind to the type II Activin receptor triggering phosphorylation of type I Activin receptor (ALK4) and activation of downstream pathways such as proliferation and apoptosis. Activin acts as a tumor suppressor by reducing cell proliferation in cancer cells.
外觀
Lyophilized from 0.2 μm-filtered solution in phosphate buffered saline containing carbohydrates.
免責聲明
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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儲存類別代碼
11 - Combustible Solids
水污染物質分類（WGK）
WGK 1
閃點（°F）
Not applicable
閃點（°C）
Not applicable
Nobuya Daitoku et al.
Oncology reports, 47(6) (2022-04-22)
Activin A is a member of the transforming growth factor‑β superfamily of cytokines and displays various pathophysiological activities, including regulation of muscle catabolism and atrophy. Activin A expression is upregulated in several human cancer types and in certain pathologies, its expression is
Kun-Ming Rau et al.
Anticancer research, 31(5), 1713-1720 (2011-05-28)
Molecular mechanisms responsible for carcinogenesis in upper urinary tract urothelial carcinoma (UUTUC) are not yet clear. This study aimed to examine and correlate the subcellular localization of activin A, maspin, and the androgen receptor (AR) with demographic characteristics, pathological grade
Activin Signaling and Its Role in Regulation of Cell Proliferation, Apoptosis, and Carcinogenesis.
Chen, Y. et. Al
Exp. Biol. Med, 231, 534-544 (2006)
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