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Amino Acid Sequence
His-Ser-Asp-Gly-Ile-Phe-Thr-Asp-Ser-Tyr-Ser-Arg-Tyr-Arg-Lys-Gln-Met-Ala-Val-Lys-Lys-Tyr-Leu-Ala-Ala-Val-Leu-Gly-Lys-Arg-Tyr-Lys-Gln-Arg-Val-Lys-Asn-Lys-NH2
一般說明
垂体腺苷酸环化酶激活多肽38（PACAP38）定位于人类染色体18。27个残基的酰胺化片段（PACAP27）包含另一个同种型。PACAP38是与哺乳动物有关的主要同种型。
應用
垂体腺苷酸环化酶激活多肽38已用于测试其在刺激鸡的环状AMP下丘脑和大脑皮质切片形成中的作用，并在细胞迁移试验（cell migration assay）中处理胶质母细胞瘤细胞（U87MG）以测试其抗侵袭作用。
生化／生理作用
垂体腺苷酸环化酶激活多肽38（PACAP38）是一种心脏保护剂，可有助于治疗放射诱发心脏病（RIHD）。它在心肌细胞的氧化应激过程中起保护作用。PACAP38具有抗氧化、抗细胞凋亡和抗炎特性。它与偏头痛和丛集性头痛的病理生理学有关。
PACAP-38 是一种与血管活性肠肽 (VIP) 具有高度同源性的神经肽。 据报道，它是一种神经元存活因子。
其他說明
从0.1％TFA水溶液中冻干
儲存類別代碼
11 - Combustible Solids
水污染物質分類（WGK）
WGK 3
閃點（°F）
Not applicable
閃點（°C）
Not applicable
個人防護裝備
Eyeshields, Gloves, type N95 (US)
其他客户在看
J Kinhult et al.
The European respiratory journal, 15(2), 243-247 (2000-03-08)
Pituitary adenylate cyclase-activating peptide (PACAP) 38 displays several biological activities relevant to obstructive airway disease. In this study, the occurrence of PACAP 38 in human small bronchi and corresponding pulmonary arteries was analysed immunocytochemically. The dilatory effects of this peptide
T Dickinson et al.
Neuropharmacology, 38(1), 167-180 (1999-04-08)
Peripheral nerve damage often results in the development of chronic pain states, resistant to classical analgesics. Since vasoactive intestinal polypeptide (VIP) and pituitary adenylate cyclase-activating polypeptide (PACAP) are up-regulated in dorsal root ganglion cells following peripheral nerve injury, we investigated
K Tornøe et al.
American journal of physiology. Endocrinology and metabolism, 279(6), E1413-E1425 (2000-11-30)
The concentration of pituitary adenylyl cyclase-activating polypeptide [PACAP-(1-38)] in porcine adrenal glands amounted to 14 +/- 3 pmol/g tissue. PACAP immunoreactive (PACAP-IR) fibers innervated adrenal chromaffin cells (often co-localized with choline acetyltransferase). Subcapsular fibers traversed the cortex-innervating endocrine cells and
Bernadett Tuka et al.
The journal of headache and pain, 17(1), 69-69 (2016-08-01)
Activation of the trigeminal-autonomic reflex, involving the trigeminal ganglion, the superior salivatory nucleus and the sphenopalatine ganglion (SPG) is crucial in the pathophysiology of cluster headache (CH). Since pituitary adenylate cyclase-activating polypeptide-38 (PACAP-38) is present both in the SPG and
A J Martínez-Fuentes et al.
Endocrinology, 139(12), 5116-5124 (1998-12-01)
We have recently shown that the two bioactive forms of pituitary adenylate cyclase-activating polypeptide, PACAP38 and PACAP27, stimulate GH release and GH messenger RNA (mRNA) accumulation in cultured porcine pituitary cells. However, dose- and time-related differences in the response to
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