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92131

Sigma-Aldrich

甲氧苄啶

≥99.0% (HPLC)

别名:

2,4-二氨基-5-(3,4,5-三甲氧基苄基)嘧啶, NSC 106568

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About This Item

经验公式（希尔记法）:
C14H18N4O3
CAS号:
738-70-5
分子量:
290.32
Beilstein:
625127
EC號碼:
212-006-2
MDL號碼:
MFCD00036761
分類程式碼代碼:
51285203
PubChem物質ID:
57653467
NACRES:
NA.85

生物源

synthetic

品質等級

200

化驗

≥99.0% (HPLC)

形狀

powder

顏色

white to light yellow

mp

≥199.0 °C

抗生素活性譜

Gram-negative bacteria
Gram-positive bacteria
mycobacteria

作用方式

DNA synthesis | interferes
enzyme | inhibits

儲存溫度

2-8°C

SMILES 字串

COc1cc(Cc2cnc(N)nc2N)cc(OC)c1OC

InChI

1S/C14H18N4O3/c1-19-10-5-8(6-11(20-2)12(10)21-3)4-9-7-17-14(16)18-13(9)15/h5-7H,4H2,1-3H3,(H4,15,16,17,18)

InChI 密鑰

IEDVJHCEMCRBQM-UHFFFAOYSA-N

基因資訊

human ... DHFRP1(573971) , KCNH1(3756)
rat ... Dhfr(24312)

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相关类别

一般說明

化学结构：嘧啶

應用

甲氧苄啶主要用作抗菌剂。用于结核分枝杆菌的敏感性研究和流感嗜血杆菌的耐药性研究。
主要作为抗细菌剂。 二氢叶酸还原酶抑制活性和原核酶选择性。

生化／生理作用

甲氧苄啶是一种二氢叶酸还原酶抑制剂，对原核生物酶具有选择性。
通过原核生物特异的二氢叶酸还原酶（DHFR）抑制四氢叶酸的合成。

包裝

1g、5g、25g

其他說明

将容器密闭保存在干燥通风的地方。对光敏感。在惰性气体下储存。对水分敏感。产品对光和水分敏感。

象形圖

Health hazardExclamation mark
GHS08,GHS07

訊號詞

Warning

危險聲明

H302,H361d

危險分類

Acute Tox. 4 Oral - Repr. 2

儲存類別代碼

11 - Combustible Solids

水污染物質分類（WGK）

WGK 3

閃點（°F）

Not applicable

閃點（°C）

Not applicable

個人防護裝備

Eyeshields, Gloves, type N95 (US)

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R de Groot et al.
Antimicrobial agents and chemotherapy, 32(4), 477-484 (1988-04-01)
We studied 10 trimethoprim-resistant (Tmpr) Haemophilus influenzae isolates for which agar dilution MICs were 10 to greater than 200 micrograms/ml. Trimethoprim resistance was transferred from two Tmpr H. influenzae isolates to a Tmps strain by conjugation or transformation. Wild-type Tmpr
Susceptibility of Mycobacterium tuberculosis to sulfamethoxazole, trimethoprim and their combination over a 12 year period in Taiwan.
Tsi-Shu Huang1,2,3, Calvin M. Kunin, et al.
The Journal of Antimicrobial Chemotherapy, 10, 633-637 (2011)
Kate S Baker et al.
The Lancet. Infectious diseases, 15(8), 913-921 (2015-05-06)
Shigellosis is an acute, severe bacterial colitis that, in high-income countries, is typically associated with travel to high-risk regions (Africa, Asia, and Latin America). Since the 1970s, shigellosis has also been reported as a sexually transmitted infection in men who
Kyuho Han et al.
Nature methods, 11(1), 86-93 (2013-11-12)
Protein concentrations are often regulated by dynamic changes in translation rates. Nevertheless, it has been challenging to directly monitor changes in translation in living cells. We have developed a reporter system to measure real-time changes of translation rates in human
Sohei Harada et al.
Antimicrobial agents and chemotherapy, 54(9), 3545-3550 (2010-06-23)
Integrating conjugative elements (ICEs) are mobile genetic elements that can transfer from the chromosome of a host to the chromosome of a new host through the process of excision, conjugation, and integration. Although SXT/R391-related ICEs, originally demonstrated in Vibrio cholerae
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