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Merck
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Key Documents

68059

Sigma-Aldrich

FITC-CM-葡聚糖

average mol wt 4,000

别名:

FITC-CM-葡聚糖4, 异硫氰酸荧光素酯–羧甲基–葡聚糖, 异硫氰酸荧光素-羧甲基-右旋糖酐

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About This Item

分類程式碼代碼:
12352116
NACRES:
NA.32

生物源

synthetic

品質等級

100

共軛

FITC conjugate

形狀

powder or crystals

分子量

average mol wt 4,000

成份

carboxymethyl content, 3-7%

標籤範圍

0.001-0.020 mol/mol FITC glucose

技術

permeability assay: suitable

螢光

λex 493 nm; λem 517 nm±5 nm in 0.1 M Tris pH 8.0

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一般說明

FITC-CM-葡聚糖，也称异硫氰酸荧光素–羧甲基–葡聚糖，是一种阴离子荧光探针。羧基提供了负电荷，其改善分子的总体渗透性。它是以黄色粉末形式供货，易溶于水和电解质溶液。FITC-CM-葡聚糖不溶于大多数有机样品，如乙醇、甲醇、丙酮和氯仿。FITC-CM-葡聚糖是通过选定的葡聚糖与活化的羧甲基衍生物在碱中反应制造，通过反应O-甲氧基被引入葡聚糖链。

應用

FITC-CM-葡聚糖用于研究HeLa 细胞系中的药物摄入和输送机制。选择FITC-CM-葡聚糖是因为其水溶性高并带负电。 它也是胶囊化研究的合适分子，可用于聚合物囊泡药物递送体系（或称Ps DDS）。选择FITC-CM-葡聚糖是一种生物相容性分子，可用作多种制药和诊断应用中的起始原料。

儲存類別代碼

11 - Combustible Solids

水污染物質分類（WGK）

WGK 3

閃點（°F）

Not applicable

閃點（°C）

Not applicable

分析证书(COA)

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Stefanie J Anderson et al.
Comparative medicine, 69(1), 4-15 (2018-12-14)
Here we characterized the murine dextran sulfate sodium (DSS) model of acute colitis. Specifically, we evaluated azithromycin and metronidazole treatment regimens to assess their effects on animal wellbeing, pathologic changes, barrier function, cytokine and chemokine profiles, and neutrophil migration in
Yuxin Leng et al.
PloS one, 9(10), e109350-e109350 (2014-10-09)
Intra-abdominal hypertension (IAH) is known as a common, serious complication in critically ill patients. Bacterial translocation and permeability changes are considered the pathophysiological bases for IAH-induced enterogenic endotoxemia and subsequent multiorgan failure. Nevertheless, the effects of slightly elevated intra-abdominal pressures
Yuxin Leng et al.
Scientific reports, 6, 22814-22814 (2016-03-17)
Intra-abdominal hypertension (IAH) is a common and serious complication in critically ill patients for which there is no well-defined treatment strategy. Here, we explored the effect of IAH on multiple intestinal barriers and discussed whether the alteration in microflora provides
Reduced diffusion of charge-modified, conformationally intact anionic Ficoll relative to neutral Ficoll across the rat glomerular filtration barrier in vivo.
Axelsson J, Sverrisson K, Rippe A, et al.
American Journal of Physiology: Renal Physiology, 301, F708-F712 (2011)
Carrier and dose effects on the pharmacokinetics of T-0128, a camptothecin analogue-carboxymethyl dextran conjugate, in non-tumor- and tumor-bearing rats.
Harada M, Murata J, Sakamura Y, et al.
J. Controlled Release, 71, 71-86 (2001)
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