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product name
组胺 二盐酸盐, ≥99.0% (AT)
化驗
≥99.0% (AT)
形狀
powder or crystals
燃燒殘留物
≤0.2%
損耗
≤0.2% loss on drying, 20 °C (HV)
mp
244-247 °C
249-252 °C (lit.)
溶解度
H2O: 0.1 g/mL, clear, colorless
負離子痕跡
sulfate (SO42-): ≤200 ppm
正離子痕跡
Ca: ≤10 mg/kg
Cd: ≤5 mg/kg
Co: ≤5 mg/kg
Cr: ≤5 mg/kg
Cu: ≤5 mg/kg
Fe: ≤5 mg/kg
K: ≤50 mg/kg
Mg: ≤5 mg/kg
Mn: ≤5 mg/kg
Na: ≤50 mg/kg
Ni: ≤5 mg/kg
Pb: ≤5 mg/kg
Zn: ≤5 mg/kg
SMILES 字串
Cl[H].Cl[H].NCCc1c[nH]cn1
InChI
1S/C5H9N3.2ClH/c6-2-1-5-3-7-4-8-5;;/h3-4H,1-2,6H2,(H,7,8);2*1H
InChI 密鑰
PPZMYIBUHIPZOS-UHFFFAOYSA-N
基因資訊
human ... HRH1(3269)
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一般說明
组胺是通过L-组氨酸脱羧酶使组氨酸发生脱羧而衍生出的一种亲水性胺。组胺已在多种生理过程中显示出作用，如胃分泌、神经传递、免疫反应、血管舒张和炎症。 此外，已有研究报道了组胺二盐酸盐与白介素2（IL-2）在治疗急性髓细胞性白血病和预防酒精引起的大鼠肝损伤中的作用。
生化／生理作用
组胺二盐酸盐已被证明可激活一氧化氮合成酶并抑制活性氧（ROS）的产生。组胺二盐酸盐对ROS的抑制使得IL-2可以激活T细胞和NK细胞。在大鼠模型中，组胺二盐酸盐通过H2组胺受体抑制由Kupffer细胞产生的ROS。
其他說明
用于组胺-N-甲基转移酶（EC 2.1.1.8）检测的底物；生物体液中组胺的离子对提取用于通过带有荧光检测的HPLC对其进行测定
訊號詞
Danger
危險分類
Eye Irrit. 2 - Resp. Sens. 1 - Skin Irrit. 2 - Skin Sens. 1 - STOT SE 3
標靶器官
Respiratory system
儲存類別代碼
11 - Combustible Solids
水污染物質分類（WGK）
WGK 2
閃點（°F）
Not applicable
閃點（°C）
Not applicable
個人防護裝備
dust mask type N95 (US), Eyeshields, Faceshields, Gloves
其他客户在看
J. Axelrod
Methods in Enzymology, 17B, 766-766 (1971)
Lily P H Yang et al.
Drugs & aging, 28(4), 325-329 (2011-03-25)
Histamine dihydrochloride (Ceplene®) is a synthetic derivative of the biogenic amine histamine. Histamine dihydrochloride inhibits the formation of reactive oxygen species that suppress the activation of T cells and natural killer (NK) cells. When given in addition to the cytokine
D Tsikas et al.
Journal of chromatography, 614(1), 37-41 (1993-04-21)
A procedure for the selective ion-pair extraction of histamine from various biological fluids and tissues by using the ion-pairing agent bis(2-ethylhexyl)hydrogen-phosphoric acid has been developed. This procedure enabled routine determination of histamine in plasma, urine and tissue samples of humans
Stephen C Hornyak et al.
Inflammation, 27(5), 317-327 (2003-11-26)
Inflammation of the liver may be caused by a variety of factors that include infectious agents and toxins. Reactive oxygen species (ROS) generated by the NADPH oxidase in Kupffer cells and infiltrating leukocytes play an important role in the pathogenesis
Yogesh Dahiya et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 39(40), 7934-7946 (2019-08-16)
Memory formation is crucial for the survival of animals. Here, we study the effect of different crh-1 [Caenorhabditis elegans homolog of mammalian cAMP response element binding protein 1 (CREB1)] isoforms on the ability of C. elegans to form long-term memory
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