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Merck

50644

Sigma-Aldrich

N-羟乙酰神经氨酸

≥95% (HPLC)

别名:

Neu5Glc, NeuNGl

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About This Item

经验公式(希尔记法):
C11H19NO10
CAS号:
分子量:
325.27
Beilstein:
1716828
MDL號碼:
分類程式碼代碼:
12352201
PubChem物質ID:

生物源

synthetic

品質等級

化驗

≥95% (HPLC)

形狀

powder

儲存溫度

−20°C

SMILES 字串

[H][C@]1(O[C@@](O)(C[C@H](O)[C@H]1NC(=O)CO)C(O)=O)[C@H](O)[C@H](O)CO

InChI

1S/C11H19NO10/c13-2-5(16)8(18)9-7(12-6(17)3-14)4(15)1-11(21,22-9)10(19)20/h4-5,7-9,13-16,18,21H,1-3H2,(H,12,17)(H,19,20)/t4-,5+,7+,8+,9+,11-/m0/s1

InChI 密鑰

FDJKUWYYUZCUJX-AJKRCSPLSA-N

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應用

甘氨酰神经氨酸,一种非人类乳汁和初乳的成分,被用作引用来分析泌乳期中甘氨酸的变化。甘氨酰神经氨酸是一种异种抗原,在异种移植过程中参与抗原反应(抗体介导的超急性排斥反应)。

其他說明

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N-羟乙酰神经氨酸在大鼠和小鼠肝脏中生物合成的调节
销售限制可能适用

儲存類別代碼

11 - Combustible Solids

水污染物質分類(WGK)

WGK 3

閃點(°F)

Not applicable

閃點(°C)

Not applicable

個人防護裝備

Eyeshields, Gloves, type N95 (US)


历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

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Potential impact of the non-human sialic acid N-glycolylneuraminic acid on transplant rejection risk.
Vered Padler-Karavani et al.
Xenotransplantation, 18(1), 1-5 (2011-02-24)
Xing Yu et al.
Journal of virology, 86(24), 13456-13466 (2012-10-05)
The rotavirus spike protein domain VP8* is essential for recognition of cell surface carbohydrate receptors, notably those incorporating N-acylneuraminic acids (members of the sialic acid family). N-Acetylneuraminic acids occur naturally in both animals and humans, whereas N-glycolylneuraminic acids are acquired
Nobuyoshi Hayashi et al.
Cancer science, 104(1), 43-47 (2012-09-26)
Gangliosides are glycosphingolipids found on the cell surface. They act as recognition molecules or signal modulators and regulate cell proliferation and differentiation. N-glycolylneuraminic acid (NeuGc)-containing gangliosides have been detected in some neoplasms in humans, although they are usually absent in
A Lepers et al.
European journal of biochemistry, 193(3), 715-723 (1990-11-13)
The relative contribution of N-glycoloyl-beta-D-neuraminic acid (Neu5Gc) to total sialic acids expressed in mouse and rat liver glycoconjugates was found to be 95% and 11%, respectively. This considerable difference in sialic acid composition made these two tissues suitable models for
Rachel E Taylor et al.
The Journal of experimental medicine, 207(8), 1637-1646 (2010-07-14)
The nonhuman sialic acid N-glycolylneuraminic acid (Neu5Gc) is metabolically incorporated into human tissues from certain mammalian-derived foods, and this occurs in the face of an anti-Neu5Gc "xeno-autoantibody" response. Given evidence that this process contributes to chronic inflammation in some diseases

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