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Merck
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主要文件

460R-1

Sigma-Aldrich

Heat Shock Protein 70 (EP377) Rabbit Monoclonal Primary Antibody

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About This Item

分類程式碼代碼:
12352203

生物源

rabbit

品質等級

100
500

共軛

unconjugated

抗體表格

culture supernatant

抗體產品種類

primary antibodies

無性繁殖

EP377, monoclonal

描述

For In Vitro Diagnostic Use in Select Regions

形狀

buffered aqueous solution

物種活性

human

包裝

vial of 0.1 mL concentrate (460R-14)
vial of 0.1 mL concentrate Research Use Only (460R-14-RUO)
vial of 0.5 mL concentrate (460R-15)
vial of 1.0 mL concentrate (460R-16)
vial of 1.0 mL concentrate Research Use Only (460R-16-RUO)
vial of 1.0 mL pre-dilute Research Use Only (460R-17-RUO)
vial of 1.0 mL pre-dilute ready-to-use (460R-17)
vial of 7.0 mL pre-dilute ready-to-use (460R-18)
vial of 7.0 mL pre-dilute ready-to-use Research Use Only (460R-18-RUO)

製造商/商標名

Cell Marque®

技術

immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:25-1:100 (concentrated)

同型

IgG

控制

hepatocellular carcinoma

運輸包裝

wet ice

儲存溫度

2-8°C

視覺化

cytoplasmic, nuclear

基因資訊

human ... HSPA1A(3303)

一般說明

The Heat Shock Protein 70 family of highly conserved chaperone proteins increase in expression upon exposure to stress factors such as temperature shock, hypoxia, oxidative stress, and pH change. This promotes cell survival by repairing misfolded proteins and preventing protein aggregates, among other functions. Likewise, tumor cells can use this mechanism to confer a survival advantage as demonstrated in Heat Shock Protein 70 overexpression in hepatocellular carcinoma.

品質

United States - IVD
European Union - IVD
Japan - RUO

外觀

Solution in Tris Buffer, pH 7.3-7.7, with 1% BSA and <0.1% Sodium Azide.

準備報告

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其他說明

For Technical Service please contact: 800-665-7284 or email: service@cellmarque.com

法律資訊

Cell Marque is a registered trademark of Merck KGaA, Darmstadt, Germany

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儲存類別代碼

12 - Non Combustible Liquids

水污染物質分類(WGK)

WGK 2


历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

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Eun Shin et al.
Journal of hepato-biliary-pancreatic sciences, 18(4), 544-550 (2011-01-15)
Heat shock protein 70 (HSP70) and glutamine synthetase (GS) have been proposed to be promising markers for the differentiation of malignant and benign hepatocellular lesions. The aim of this study was to investigate the clinicopathological significance of the expression of
Maureen E Murphy
Carcinogenesis, 34(6), 1181-1188 (2013-04-09)
The HSP70 family of heat shock proteins consists of molecular chaperones of approximately 70kDa in size that serve critical roles in protein homeostasis. These adenosine triphosphatases unfold misfolded or denatured proteins and can keep these proteins in an unfolded, folding-competent
Luca Di Tommaso et al.
Journal of hepatology, 50(4), 746-754 (2009-02-24)
Liver biopsy for hepatocellular carcinoma (HCC) detection is largely restricted to small hepatocellular lesions, which are often morphologically challenging, requiring careful distinction between dysplastic nodules (high-grade) and well-differentiated HCC. We investigated the diagnostic accuracy of a panel of markers (HSP70

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