推荐产品
生物源
mouse
品質等級
100
500
共軛
unconjugated
抗體表格
diluted ascites fluid
抗體產品種類
primary antibodies
無性繁殖
R4A, monoclonal
描述
For In Vitro Diagnostic Use in Select Regions (See Chart)
形狀
buffered aqueous solution
物種活性
human
包裝
vial of 0.1 mL concentrate (377M-14)
vial of 0.5 mL concentrate (377M-15)
bottle of 1.0 mL predilute (377M-17)
vial of 1.0 mL concentrate (377M-16)
bottle of 7.0 mL predilute (377M-18)
製造商／商標名
Cell Marque®
技術
immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:100-1:500
同型
IgG1
控制
bladder, leiomyoma
運輸包裝
wet ice
儲存溫度
2-8°C
視覺化
cytoplasmic, nuclear
基因資訊
human ... SMTN(6525)
一般說明
Smoothelin is a constituent of the smooth muscle cell cytoskeleton protein exclusively found in differentiated smooth muscle cells (SMC). Cells with SMC-like characteristics, such as myofibroblasts and myoepithelial cells, as well as skeletal and cardiac muscle do not contain smoothelin. To distinguish bladder muscularis mucosae (MM) from muscularis propria (MP) muscle bundles is crucial for accurate staging of bladder carcinoma. Strong smoothelin expression is nearly exclusively observed in muscularis propria. Therefore, the staining pattern of MP (strongly positive) and MM (negative or weakly positive) makes this technique an attractive diagnostic tool for the sometimes difficult task of staging bladder urothelial carcinoma, such as in transurethral resection specimens of urinary bladder tumors. Differentiating between smooth muscle tumors and other mesenchymal neoplasms of the GI tract can be challenging in small biopsies. Anti-smoothelin immunostaining can be helpful in differentiating benign (+) from malignant smooth muscle tumors (-), and other mimics(-).
品質
 IVD |  IVD |  IVD |  RUO |
聯結
Smoothelin Positive Control Slides, Product No. 377S, are available for immunohistochemistry (formalin-fixed, paraffin-embedded sections).
外觀
Solution in Tris Buffer, pH 7.3-7.7, with 1% BSA and <0.1% Sodium Azide
準備報告
Download the IFU specific to your product lot and formatNote: This requires a keycode which can be found on your packaging or product label.
其他說明
For Technical Service please contact: 800-665-7284 or email: service@cellmarque.com
法律資訊
Cell Marque is a registered trademark of Merck KGaA, Darmstadt, Germany
未找到合适的产品？
试试我们的产品选型工具.
C Maake et al.
The Journal of urology, 175(3 Pt 1), 1152-1157 (2006-02-14)
We established the expression pattern of smoothelin, a marker protein for contractile smooth muscle cells, in the human detrusor and investigated its possible impact on bladder overactivity. Detrusor samples of 13 overactive bladders (sensory urge and detrusor instability) were obtained
Gladell P Paner et al.
The American journal of surgical pathology, 33(1), 91-98 (2008-10-22)
Accurate recognition of urinary bladder muscularis propria (MP) invasion by urothelial carcinoma is crucial as it is the critical crossroad between conservative and aggressive management for the patient. It is now widely known that an inconsistent layer of muscularis mucosae
Gladell P Paner et al.
The American journal of surgical pathology, 34(6), 792-799 (2010-04-28)
Accurate recognition of muscularis propria invasion by urothelial carcinoma is vital as it serves as a crossroad between conservative and aggressive clinical management. Recently, there has been attention to the hyperplastic pattern of muscularis mucosae which may mimic the muscularis
R E Jimenez et al.
Advances in anatomic pathology, 7(1), 13-25 (2000-01-20)
One of the challenging areas in genitourinary pathology is the recognition of early invasion in urothelial neoplasia. Not uncommon, the patterns of invasion into lamina propria are subtle because a desmoplastic response is absent. Tangential sectioning due to inability to
Dominique P Coco et al.
The American journal of surgical pathology, 33(12), 1795-1801 (2009-12-02)
Smoothelin is a smooth muscle-specific cytoskeletal protein exclusively found in differentiated smooth muscle cells. This contrasts with other smooth muscle proteins (eg, h-caldesmon, alpha-smooth muscle actin, desmin, smooth muscle myosin), which are expressed in proliferative (early) stages of smooth muscle
我们的科学家团队拥有各种研究领域经验，包括生命科学、材料科学、化学合成、色谱、分析及许多其他领域.
联系技术服务部门