17946

1α-Hydroxyvitamin D₃

≥97.0% (HPLC)

• 别名: 1α-Hydroxycholecalciferol, Alfacalcidol
• 经验公式（希尔记法）: C₂₇H₄₄O₂
• CAS号: 41294-56-8
• 分子量: 400.64
• EC號碼: 255-297-1
• MDL號碼: MFCD00868328
• 分類程式碼代碼: 12352205
• PubChem物質ID: 57647693
• NACRES: NA.79

属性

• 生物源: synthetic
• 化驗: ≥97.0% (HPLC)
• 形狀: powder or crystals
• 顏色: white to off-white
• 儲存溫度: −20°C
• SMILES 字串: CC(C)CCC[C@@H](C)[C@H]1CC[C@H]2\C(CCC[C@]12C)=C\C=C3\C[C@@H](O)C[C@H](O)C3=C
• InChI: 1S/C27H44O2/c1-18(2)8-6-9-19(3)24-13-14-25-21(10-7-15-27(24,25)5)11-12-22-16-23(28)17-26(29)20(22)4/h11-12,18-19,23-26,28-29H,4,6-10,13-17H2,1-3,5H3/b21-11+,22-12-/t19-,23-,24-,25+,26+,27-/m1/s1
• InChI 密鑰: OFHCOWSQAMBJIW-AVJTYSNKSA-N
• 基因資訊: human ... VDR(7421)

说明

一般說明

1α-Hydroxyvitamin D₃, also known as alfacalcidol, is a synthetic vitamin D₃ analogue, hydroxylated in position one. It is metabolized to 1,25-dihydroxycholecalciferol by 25-hydroxylases.

生化／生理作用

1α-Hydroxyvitamin D₃ facilitates calcium absorption and deposition. It also has an ability to inhibit bone resorption and stimulate bone formation. Alfacalcidol is used for treating various bone diseases such as rickets/osteomalacia, renal osteodystrophy and osteoporosis. It acts as a chemopreventive agent and reduces the risk colitis and carcinogenesis.

Synthetic vitamin D₃ analog that is metabolized to 1,25-dihydroxycholecalciferol. Inhibits bone resorption and stimulates bone formation. Supresses parathyroid hormone secretion by bovine parathyroid cells.

包裝

Bottomless glass bottle. Contents are inside inserted fused cone.

安全信息

• 象形圖: GHS06
• 訊號詞: Danger
• 危險聲明: H300
• 防範說明: P301 + P330 + P331 + P310
• 危險分類: Acute Tox. 1 Oral
• 儲存類別代碼: 6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials
• 水污染物質分類（WGK）: WGK 3
• 閃點（°F）: Not applicable
• 閃點（°C）: Not applicable
• 個人防護裝備: Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges